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Phase III – New Testing Technology

Researchers developed new testing technology to allow further progress in research into subtle multisymptom illness (2001–2007).

A. Developed new statistical technology to increase the power of neuroimaging studies

  1. Spatial modeling (kriging) method for increased power in comparing groups of ill and well veterans. [References]
  2. Improved methods of spatially aligning and indexing brain images for analysis [References]
  3. Novel methods for designing and analyzing functional MRI (fMRI) studies [References]
  4. Improved method for analyzing EEG studies [References]
    U.S. patent no. 7,961,922 B2 “Systems and methods for processing medical image data to facilitate comparisons among groups of subjects” was issued June 14, 2011.

B. New neuroimaging technology to allow detection of subtle differences in brain structure, function or chemistry

  1. Arterial spin labeling (Briggs/Li) [References]
    U.S. Patent Number 8,143,892 "System and methods for active suppression of superior tagging in flow-sensitive alternating inversion recovery" was issued March 27, 2012.
  2. Cholinergic challenge experiment (Haley) [References]
  3. MR spectroscopy (Briggs/Cheshkov) [References]
  4. Quantitative sensory fMRI (Gopinath) [References]
  5. Functional connectivity fMRI (Gopinath) [References]
  6. Emotional memory circuits fMRI (Kraut/Ringe) [References]
  7. Material-specific encoding memory fMRI (Ringe) [References]
  8. Attention and executive function fMRI (Rypma) [References]
  9. Word retrieval fMRI (Hart)
  10. Auditory & visual memory fMRI (Odegard)
  11. Complex verbal functions fMRI (Crosson)

C. New EEG technology

  1. New statistical approaches to analysis of EEG [References]
  2. Resting EEG
  3. Functional EEG [References]

D. Engineering enhancements to 3T MRI scanner to increase measurement power

  1. Noise control in a 3T MRI scanner [References]
  2. Optical head tracking [References]
    U.S. Patent Number 7,498,811 "Apparatus and method for patient movement tracking" was issued March 3, 2009.
    U.S. Patent Number 8,390,291 B2 "Apparatus and method for tracking movement of a target" was issued March 5, 2013.
  3. Enhanced registration of brain images [References]

E. Method for measuring serum activity of Q and R isoenzymes of paraoxonase 1 (PON1) [References]

Phase III was funded by the U.S. Army Medical Research & Materiel Command at Ft. Detrick