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The Biomarker Research Core (BRC) is focused on supporting investigator-initiated cancer clinical trials.

Contact Us To address any questions, reserve instrument time, or arrange MBR services, please MBR@utsouthwestern.edu MBR. Location: ND10.214B Phone: 214-645-6384 Chad A. Brautigam, Ph.D. Director Professor Shih-Chia (Scott) Tso, Ph.D. Senior Research Associate Back-to top

Software GUSSI GUSSI is a program that can illustrate the output of SEDFIT and SEDPHAT. In some cases, it can perform some simple calculations with the data. It is designed to work with sedimentation velocity, sedimentation equilibrium, ITC, DLS, and isotherm data. Examples of GUSSI's Output View GUSSI Gallery Download GUSSI After you click the Access button below, click the "Download" button at the top of the following page. Access GUSSI for Download View GUSSI Terms & Installation Instructions

Publications Bret M. Evers, M.D., Ph.D. James A. Richardson D.V.M., Ph.D., Diplomate (ACVP) John M. Shelton, B.Sc. Contact Us UT Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, Texas 75390-8573 Phone: 214-648-1137 Fax: 214-648-1450 Quick Links Department of Molecular Biology Department of Pathology Research Labs Back-to top

Services Anatomic Pathology Client Microscopy Facilities Critical Anatomy/IHC Histopath Consultation Routine Histology Special Stains Specialized Techniques Contact Us UT Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, Texas 75390-8573 Phone: 214-648-1137 Fax: 214-648-1450 Back-to top

STED (access provided through the Peter O'Donnell Jr. Brain Institute) This system is owned by the Peter O'Donnell Jr. Brain Institute. The Abberior Facility Line system is a cutting-edge, high-end 3-D STED super-resolution imaging system capable of providing 40 nm isotropic resolution in samples up to 70 µm thick - xy down to 25nm. Adaptive Illumination (RESCue, DyMIN and MINFIELD) provides less phototoxicity and drastically reduces photobleaching. Adaptive Optics System with Deformable Mirror

2021 Publications Li J, Canseco D, Wang Y, Vale G, Chaudhary J, Anwar A, Baniasadi H, Williams NS , Gopal P, Sutphin PD, McDonald JG, Putnam WC, Corbin IR. Assessing the safety of transarterial locoregional delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat liver. Eur J Pharm Biopharm . 2021 Jan;158:273-283. PMCID: PMC8121338. Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F , Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS , Krysan DJ, Privé GG

Cytochrome P450 Inhibition Currently under Redevelopment Because of the important role of Cytochrome p450 enzymes in drug metabolism, it is important to assess the ability of lead compounds to inhibit specific cytochrome p450 enzymes to avoid potential drug-drug interactions where one drug may affect the metabolism of another. This assay is only recommended for advanced leads. Typical Assay Conditions Isoform Source Substrate Positive Inhibitor 1A2 BD Bioscience Supersome phenacetin furfylline

Cancellation/No-show Due to the heavy use of our microscopes, we require that if you have to cancel your session, you do so at least 12 hours before the scheduled start time. If you cannot connect to the scheduler or are within the 12-hour time window, please QLMC@utsouthwestern.edu . Failure to cancel in time will result in an invoice for the entire scheduled duration. Back-to top

Zeiss LSM780 Upright (ND5.740) Upright confocal microscope configured for organ culture and whole animal imaging Visible laser lines 405, 458, 488, 514, 561, 594, 633 nm. Coherent Vision II laser for two-photon imaging and SHG Spectral detection with ultrasensitive GaAsP detector Two non-descanned detectors for deep imaging Objectives: 10x (NA 0.3 and 0.45), 20x (NA 0.8 and 1), 32x (NA 0.85), 40x (NA 1.1 and 1.3), 63x (NA 1.4) Motorized stage Temperature control Sign Up Back-to top