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Photo Gallery Cells expressing H2B-PSmOrange Live cells expressing H2B-PSmOrange were used to photoconvert PSmOrange from red into far red, using a binarized image of the Mona Lisa. Although not scientific, this image highlights the capabilities and precision of modern microscopes. The image was acquired on a Nikon spinning disk confocal with FRAP module. Objective: 100x/1.45 NA. Etai Saponzik, Fiolka lab, kindly provided cells. RPE-1 cells were imaged every 6 seconds for 10 minues a Tomocube HT

Recent News Now offering crosslinking analysis! September 23, 2024 We now offer crosslinked protein analysis, using XQuest software. Please contact us if you have questions about this service. Now offering ubiquitination enrichment August 9, 2023 We now offer ubiquitinated peptide enrichment, using the PTMScan® Ubiquitin Remnant Motif (K-ε-GG) Kit from Cell Signaling Technology. Please contact the Proteomics Core for questions regarding this service. Price increase for plasma/serum abundant

The Structural Biology Core Facility provides a unique platform for biochemists and molecular biologists to engage in structural biology projects by making macromolecular crystallography available as a general tool.

Cite the UT Southwestern NORC The National Institutes of Health requires that investigators cite our grant in all publications, posters, press releases, proposals, abstracts and/or presentations resulting from the use of any of our cores’ services. Our productivity and effectiveness as a Center is measured in part by the citation of the grant in your published work. Please acknowledge National Institutes of Health grant P30DK127984 in all publications resulting from the use of our cores

Contact Location & Hours The Proteomics Core is located in rooms Y4.306 (Lab) and Y4.310 (Office) of the Green Biomedical Research (Y) Building. Samples can be dropped off in Y4.106, 24 hours a day. Please contact ProteomicsCore@UTSouthwestern.edu once you have dropped off samples or with questions. Inquiry System We use an inquiry ticket system to ensure that all relevant core staff can access and respond to queries, and that inquires are answered promptly even if an individual member of staff

Contact Us Core Director Noelle S. Williams, Ph.D. Director Professor in Biochemistry Education Ph.D., Microbiology – University of Virginia, Charlottesville, VA B.S., Biology – Trinity University, San Antonio, TX Contact Information Location: L4.244 Office Phone: 214-648-5072 Lab Phone: 214-648-0348 Fax: 214-648-8856 Lab Location: L4.244 Shipping Address Noelle Williams Southwestern Medical Center Central Supply Warehouse, XA100 2929 N. Stemmons Freeway Dallas, TX 75247-9056 Attn: Room L4.244

Pricing & Services The Preclinical Pharmacology Core offers a range of services associated with preclinical drug development and pharmacokinetics on a fee-for-service or collaborative grant-funded basis. See list at left for details of our services. Assay costs vary with the complexity of the study but are built based on prices from the Pricing section. Please inquire with the Core director regarding pricing for your particular project. New projects require consultation with the Core director

Resourses Collaborating Facilities at UT Southwestern Core Facilities Centers and Institutes Advanced Imaging Research Center (AIRC) Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology Cecil H. and Ida Green Center for Reproductive Biology Sciences Center for Alzheimer's and Neurodegenerative Diseases Center for the Genetics of Host Defense Center for Human Nutrition Center for Translational Medicine Center for Translational Neurodegeneration Research

Publications Recent publications (core staff in bold) Wang W, Ranjan A, Zhang W, Liang Q, MacMillan KS, Chapman K, Wang X , Chandrasekaran P, Williams NS , Rosenbaum DM, De Brabander JK. Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorg Med Chem Lett . 2024 Feb 1; 99 : 129624 . PubMed PMID: 38272190 . Prakasam G, Mishra A, Christie A, Miyata J, Carrillo D, Tcheuyap VT, Ye H, Do QN, Wang Y, Reig Torras O, Butti R, Zhong H, Gagan J, Jones KB

Data acquired on the NMR Core spectrometers can be instantly and easily accessed remotely on the facility’s samba server via network drives.