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Critical Anatomy/ISH The Histo Pathology Core is based upon the premise that research-oriented histology is about meeting the client investigators' need for critical anatomy. The lab is well versed in: Performing dark-field assisted cut-and-look microtomy to meet comparative anatomy between specimens. Matching specific sectioning planes to Kaufman mouse embryo or Paxinos brain anatomy atlases. Matching sectioning planes to previously cut slides or anatomy depicted in journal articles. Achieving

Understand the roles and responsibilities in the Sponsored Programs Administration (SPA) process for basic science research at UT Southwestern

CMRU Core Offerings: Wet Lab Our state-of-the-art wet lab is equipped with specialized analytical tools and technologies, such as the Cobas e411 and Cobas c311 modules. These capabilities allow us to perform a wide array of diagnostic tests, from biochemical panels to drug screening, ensuring precise and timely results for your research needs. CMRU lab employs Roche's Cobas e411 and Cobas c311 analyzers to boost laboratory efficiency and diagnostic precision. The Cobas e411 is an automated

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

Aqueous Solubility Determination Poor aqueous solubility can limit the ability to develop lead compounds as in vivo probes and therapeutics. Aqueous solubility affects absorption, formulation and ability of a compound to be delivered in sufficient concentrations to be active, and even in vitro activity. The Core offers two types of assays: Thermodynamic (or Equilibrium) Solubility Measures solubility of a compound as a saturated solution in equilibrium. Solubility can be dependent on pH and the

Bioanalysis and Pharmacokinetics Bioanalysis : The Preclinical Pharmacology Core makes use of three combination triple quadrupole/ion trap mass spectrometers from AB Sciex: a 3200 QTRAP® System, a 4000 QTRAP® System, and a QTRAP ® 6500+ System. All three mass spectrometers are coupled to Shimadzu Prominence liquid chromatography instruments with 80 to 100-place autosamplers. Development of an analytical method requires several steps: optimization of an MS/MS method to detect the compound with

Plasma Protein Binding Plasma protein binding (PPB) plays an important role in the pharmacokinetics (PK) and pharmacodynamics (PD) of a drug. Free drug levels are closely related to the pharmacological effects of a compound as the principal determinant of tissue distribution, cell entry, receptor interactions, and availability for elimination. At the early stages of drug development, PPB experiments advance understanding of ADME (absorption, distribution, metabolism, excretion) properties to aid

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.

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The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.