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Sequencing Our facility is equipped with one Illumina NextSeq 2000, three NextSeq 500s, and one Miseq System. The NextSeq 2000 offers three flowcells: Flowcell # of reads Read Lengths P1 100 M 300 Cycles P2 400 M 100, 200 and 300 Cycles P3 1.2 B 50, 100, 200 and 300 Cycles The NextSeq 500 offers 5 flowcells: Flowcell # of reads Kit Capacity 75 High Output 400 M 75 Cycles 150 Mid Output 130 M 150 Cycles 150 High Output 400 M 150 Cycles 300 Mid Output 130 M 300 Cycles 300 High Output 400 M 300

Publications Recent publications (core staff in bold) Wang W, Ranjan A, Zhang W, Liang Q, MacMillan KS, Chapman K, Wang X , Chandrasekaran P, Williams NS , Rosenbaum DM, De Brabander JK. Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorg Med Chem Lett . 2024 Feb 1; 99 : 129624 . PubMed PMID: 38272190 . Prakasam G, Mishra A, Christie A, Miyata J, Carrillo D, Tcheuyap VT, Ye H, Do QN, Wang Y, Reig Torras O, Butti R, Zhong H, Gagan J, Jones KB

Contact Us Core Director Noelle S. Williams, Ph.D. Director Professor in Biochemistry Education Ph.D., Microbiology – University of Virginia, Charlottesville, VA B.S., Biology – Trinity University, San Antonio, TX Contact Information Location: L4.244 Office Phone: 214-648-5072 Lab Phone: 214-648-0348 Fax: 214-648-8856 Lab Location: L4.244 Shipping Address Noelle Williams Southwestern Medical Center Central Supply Warehouse, XA100 2929 N. Stemmons Freeway Dallas, TX 75247-9056 Attn: Room L4.244

Pricing & Services The Preclinical Pharmacology Core offers a range of services associated with preclinical drug development and pharmacokinetics on a fee-for-service or collaborative grant-funded basis. See list at left for details of our services. Assay costs vary with the complexity of the study but are built based on prices from the Pricing section. Please inquire with the Core director regarding pricing for your particular project. New projects require consultation with the Core director

PCIRCF supports radiation-based animal studies with protocol drafting, grant writing, dosimetry data, and letters of support for UTSW and UT investigators.

The PCIRCF at UT Southwestern uses iLab, an online platform that streamlines equipment reservations, consultations, and billing for core services.

Rates for Pre-Clinical Imaging/Image-Guided Radiation core Facility including Ami-HTX, MRI services, and radiation delivery

Whole Brain Microscopy Equipment The WBMF offers access to a unique set of high-throughput microscopes and histology resources, ideal for collecting high-content neuroscience data, for UT Southwestern and external researchers. Please remember to acknowledge your usage of our facility resources in your publications using our established Research Resource Identifier code anywhere in your methods or acknowledgements: RRID: SCR_017949 . This is critical for us to maintain support for the core. Jump

Whole Brain Microscopy Services & Fees 3D Volumetric Imaging and Automated Analysis We can generate high-resolution, whole-brain/whole-tissue 3D images as a full-service operation using serial two-photon tomography (STPT) or lightsheet microscopy according to specific experimental needs. Fixed specimens can be provided to the core, and we can take it from there. Core staff can perform STPT or tissue clearing using the Clear+ method, whole-brain/whole-tissue immunostaining, and lightsheet

There are sample requirements for services provided by Sanger Sequencing Core, McDermott Center. Standard primers are provided.