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Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD) models, UT Southwestern researchers reported.

While public attention has been focused on the million-plus Americans who have died from COVID-19 and the ongoing level of cases and hospitalizations, tens of millions of patients have developed life-altering symptoms that linger long after their COVID-19 infection clears.

A gene that’s well known for its role in turning on tumor-suppressing genes when cells become stressed also keeps potential tumor-driving genes turned off, UT Southwestern researchers report in a new study.

A multidisciplinary effort to improve care for older patients who arrive at the emergency room with a hip fracture has decreased the time before they have surgery, shortened hospital stays, and resulted in better follow-up care, UT Southwestern physicians reported in Geriatric Nursing.

UT Southwestern is joining with medical centers around the nation to apply advanced sequencing to pediatric brain tumors as part of the National Cancer Institute’s new Molecular Characterization Initiative, a subset of the Cancer Moonshot Childhood Cancer Initiative.

Multiple studies have demonstrated that Black patients are significantly less likely than white patients to undergo invasive cardiovascular procedures. Prior research also has demonstrated substantial racial disparities in the use of implantable cardioverter-defibrillators (ICDs) that can be

Seemingly healthy people whose blood contained antibodies associated with a condition called antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event such as a heart attack or stroke than those without, a study led by UT Southwestern scientists shows.

How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT

New technologies that can capture subtle changes in a patient’s voice may help physicians diagnose cognitive impairment and Alzheimer’s disease before symptoms begin to show.

Researchers at UT Southwestern Medical Center have been approved for an $18 million funding award from the nonprofit Patient-Centered Outcomes Research Institute (PCORI) to investigate ways to improve postpartum health among primarily low-income Black and Hispanic women.