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Simulation reveals new mechanism for membrane fusion: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/april-new-mechanism-for-membrane-fusion.html

– An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world’s most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse.

Accelerated brain aging predicts less antidepressant efficacy: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2023/aug-accelerated-brain-aging-antidepressant-efficacy.html

Patients whose brains appear older on scans than their chronological age showed less improvement on sertraline, a first-line drug treatment for major depressive disorder (MDD), researchers from UT Southwestern Medical Center reported.

Noboru Mizushima, M.D., Ph.D., awarded inaugural Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2023/june-mizushima-beth-levine-prize.html

Japanese biochemist and molecular biologist Noboru Mizushima, M.D., Ph.D., has been named the inaugural recipient of the Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern Medical Center.

How gut bacteria become ‘persisters’ to avoid antibiotics: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/feb-gut-bacteria-become-persisters.html

A subpopulation of gut bacteria given a commonly used antibiotic became “persisters” that were able to survive without developing true resistance, UT Southwestern Medical Center scientists discovered.

UT Southwestern finds genetic clues to complex infections: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/feb-genetic-clues-to-complex-infections.html

Treating complex bacterial infections with customized therapies tailored to the infection and the patient is closer to reality, thanks to researchers at UT Southwestern Medical Center.

Inducing labor with drug vaginally shows benefits in study: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/april-inducing-labor-drug-vaginally.html

Labor induction with vaginal misoprostol during childbirth achieves vaginal delivery rates similar to the oral alternative while significantly reducing the need for oxytocin, the most commonly used labor-inducing drug, UT Southwestern Medical Center researchers report.

Two Texas transplant programs team up to save lives: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/feb-two-texas-transplant-programs.html

Two hard-to-match transplant patients 250 miles apart are starting 2024 on a new path to healthy lives. That’s because UT Southwestern Medical Center’s Solid Organ Transplant Program and University Health Transplant Institute in San Antonio searched beyond their own institutional networks to

Gene therapy offers hope for giant axonal neuropathy patients: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/march-gene-therapy-axonal-neuropathy-patients.html

A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports.

Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s : Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2024/feb-gold-nanoparticles-brain-deficits.html

Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted

Personal approach reduces opioids after cesarean deliveries: Newsroom - UT Southwestern, Dallas, Texas

https://www.utsouthwestern.edu/newsroom/articles/year-2023/dec-opioids-prescribed-after-c-section.html

Tailoring prescriptions individually to a patient’s needs after cesarean delivery can decrease opioid use while successfully managing post-surgical pain, according to a new study by researchers at UT Southwestern Medical Center. The change in protocol, detailed in a study published in the American