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A team led by UT Southwestern Medical Center researchers has uncovered the atomic structure of a protein complex pivotal to the function of motile cilia, the hair-like structures extending from the surfaces of many cell types that generate their movement.

Italian medical geneticist Andrea Ballabio, M.D., an internationally recognized scientist who has devoted his career to elucidating the mechanisms underlying genetic diseases, has been named the recipient of the 2025 Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern Medical Center.

The National Institute on Aging (NIA), part of the National Institutes of Health, recently funded the North Texas Alzheimer’s Disease Research Center (ADRC) to be based at UT Southwestern Medical Center, in collaboration with UT Dallas and UT Arlington.

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows.

By using a genetic technique they developed that forces cells to rid themselves of mitochondria, UT Southwestern Medical Center researchers are gaining new insights into the function of these critical organelles.

UT Southwestern Medical Center researchers have identified two distinct populations of cells known as antigen-presenting cancer-associated fibroblasts (apCAFs) that appear to support the survival and growth of malignant tumors. Their findings, reported in Cancer Cell, could one day lead to new therapies for notoriously hard-to-treat cancers, including pancreatic cancer and advanced colorectal cancer (CRC) that has spread throughout the abdomen, known as peritoneal metastasis.

While randomized comparative trials are needed, a relatively new treatment option for upper urinary tract cancers shows promise for lowering long-term recurrence in many patients with low-grade disease, according to a multicenter study led by researchers at UT Southwestern Medical Center.

A preclinical model developed at UT Southwestern Medical Center that recapitulates a rare infant-onset form of diabetes suggests the condition stems from gradual damage to the pancreas through misregulation of a molecular pathway called the unfolded protein response (UPR).

A computer model of the cellular environment inside the knee developed by UT Southwestern Medical Center researchers sheds light on why women tend to have worse outcomes after knee injuries than men. Their findings, published in Scientific Reports, could facilitate research into new therapies for knee inflammatory disorders and personalized treatments for patients with these conditions.

Poor diets have been linked to seven of the 10 leading causes of death in the United States, from heart disease to diabetes and certain types of cancer. Yet many physicians are not equipped to counsel patients about healthy food choices, and most medical students and trainees do not receive adequate training in this discipline.