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Client Microscopy Facilities The Histo Pathology Core has microscopy facilities for clients to review and document completed histology slides, as well as to document wet tissues and cell culture preps that augment their histopathology. Self-Service Microscopy by Reservation These instruments, located…

Anatomic Pathology The Histo Pathology Core offers anatomic pathology services on an as needed basis to train clients as well as facilitate morphologic and histologic endpoints in large terminal studies with mice. The Core provides expert training in the following procedures with mice: Transcardial W…

Special Stains The Histo Pathology Core offers a wide menu of special stains for improving visualization of normal and disease state chemical moieties. Special Stains that the Core performs on a routine schedule include Oil Red-O stain for neutral lipids, Masson's Trichrome stain for collagen/fibrosi…

PTM Identification Introduction The presence or absence of post-translational modifications (PTMs), such as phosphorylation, on a protein are often as interesting as the presence of absence of the protein itself. The PTM ID service offers identification of PTMs on a protein from a purified protein or…

Publications and Expertise The staff of the proteomics core work closely with customers, and are often heavily involved in the write-up process of projects that have made use of mass spectrometry services. In addition to our co-authored papers, our work is frequently acknowledged by our researchers i…

Gel Band ID Introduction Identification of proteins from visible bands excised from Coomassie or silver-stained gels using mass-spectrometry is generally very successful. Almost all visible Coomassie bands contain enough protein for MS identification. Most silver-stain bands can be identified on our …

Guide for using the LEICA SP8 microscope.

Zeiss SteREO Discovery (NL7.110M) Zeiss motorized stereo microscope with filters for GFP, RFP, and CY5 GFP LP available for simultaneous GFP and transmitted-light imaging Automated collection of z-stacks with extended focus option Transillumination and gooseneck illumination for bright field imaging …

Zeiss LSM 780 Inverted (NL5.120N) Visible laser lines: 405, 458, 488, 514, 561, 594, and 633 nm for conventional confocal applications. Spectral detection for optimized CFP/YFP FRET and spectral unmixing of closely overlapping fluorophores (e.g. GFP and YFP, multiplexed Qdots). Tunable NIR laser for …

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.