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Patients with sickle cell disease (SCD) who undergo total knee replacement are at higher risk for complications than non-SCD patients, according to a large-scale, retrospective study by researchers from UT Southwestern Medical Center and the University of Calgary.

Seemingly healthy people whose blood contained antibodies associated with a condition called antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event such as a heart attack or stroke than those without, a study led by UT Southwestern scientists shows.

If it hurts when you grip a cup of coffee, get up from the chair, or climb the stairs, you may have osteoarthritis, one of the most common types of arthritis. And though your achy joints seem to be telling you to take it easy, that’s exactly what you should not be doing.

Researchers at UT Southwestern Medical Center have discovered how a bacterium that infects people after they eat raw or undercooked shellfish creates syringe-like structures to inject its toxins into intestinal cells.

A mammalian protein previously shown by UT Southwestern microbiologists to inhibit the virus that causes COVID-19 in cell culture also protected live mouse models, significantly limiting infection in the lung cells and diminishing the symptoms.

UT Southwestern Medical Center researchers have identified hundreds of genomic variants associated with autism spectrum disorder (ASD) in East African families who have a markedly higher prevalence of the neurodevelopmental condition than other areas worldwide.

UT Southwestern Medical Center will lead a national multicenter clinical trial to test a treatment strategy for pediatric cancer patients that has shown promising results in adults.

The outbreak of measles that started in West Texas in January and spread to other regions and states has focused renewed attention on a childhood disease that had been eliminated in the United States in recent decades.

Zhijian “James” Chen, Ph.D., Professor in the Department of Molecular Biology at UT Southwestern Medical Center and one of the world’s top researchers on innate immunity, has been awarded the 2026 Elaine Redding Brinster Prize in Science or Medicine.

Malaria, responsible for hundreds of thousands of deaths each year worldwide, is caused by a parasite transmitted through the salivary glands of female Anopheles mosquitoes. Understanding the biology of these tissues is critical to developing new treatments for the disease, found mostly in tropical countries.