Research Labs by Department
Alzheimer's and Neurodegenerative Diseases
The Bailey lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy and ECHS1 deficiency.
The Shahmoradian lab investigates the roles of domain-specific neuronal proteins using advanced cryo-imaging techniques to understand their impact on cellular dynamics and neurological health.
Biochemistry
We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis.
The Nam Lab asks how the shape of an RNA regulates its function. We study the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important for normal and disease states.
The Wang Lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.
Bioinformatics
Our research is aimed at innovating and translating computational technology to advance biomedical research and medical diagnoses/treatments.
Biomedical Engineering
We aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in the context of improving therapies.
Biophysics
Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.
Brain
The central goal of the Dauer Lab is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.
Cancer
We are working at the interface of nanotechnology, drug delivery, and tumor immunology.
Cell Biology
Our laboratory studies the cell biology of viral-host interactions.
The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.
Internal Medicine
To understand how kidney cancer develops at the molecular level, To translate our findings into new treatments for kidney cancer patients, To train the next generation of physicians and scientists.
Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.
My research interests include prevention of progression of renal diseases, diagnoses, and management of lipid disorders in renal disease, hypertensive nephrosclerosis, the role of angiotensin II converting enzyme inhibitors, and angiotensin II receptor blockers in renal disease.
Medicine/ID
The Beckham Lab is a dynamic multidisciplinary laboratory that studies viral pathogenesis and neuroimmune response.
Microbiology
Our research focuses on decoding the properties and regulation of RNA polymerases in various bacterial pathogens. By uncovering these fundamental mechanisms, we aim to lay the groundwork for the development of new antimicrobial therapies-moving toward a future where infectious diseases no longer pose a global threat.
The overarching goals of our lab are to understand the posttranscriptional mechanisms of gene expression and regulation in the Kaposi's sarcoma-associated herpesvirus (KSHV) and its human host cell. We are particularly focused on the mechanisms and regulation of nuclear RNA stability, polyadenylation, and mRNA processing by viral and by host cell factors.
At Forsberg Lab, we strive to make impactful scientific discoveries, provide an excellent training environment for future scientists and communicators, and advance the long-term goals of those in the lab.
At Phieffer Lab, we are scientists who love exploring biological mysteries. We are passionate about tractable model systems and the power of genetics because they help us reveal how complex environments influence viral infection. We think that the best science is done by a diverse and supportive team.
The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune diseases, cancer immunology, and neurodegenerative diseases.
Mineral Metabolism
The Moe Lab specializes in translational pathophysiology that spans from individual molecules, in vitro cell models, in vivo animal models, to metabolic human studies.
Molecular Biology
Buszczak Laboratory seeks to gain new insights into mRNA translation, ribosome biogenesis and germ cell biology.
The Mendell Laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.
The O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and mouse models.
Development of novel CRISPR-based therapeutic approaches for neuromuscular and cardiovascular diseases.
We seek to understand how RNA/protein assemblies control cellular states, and how related pathways are hijacked by diseases of aging.
The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.
The Wu Laboratory mainly focuses on using stem cell models to gain novel insights in mammalian development and develop regenerative medical applications.
Neurological Surgery
At the Fu Lab of human neuroscience we investigate the neural bases of cognitive control.
Neurology
The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.
The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.
Neuroscience
The goal of Lin (Weichun) Lab's research is to understand how neurons establish synaptic connections during development, and how these connections are maintained throughout adulthood. Toward this goal, we are currently focusing on the following two areas of research.
Ophthalmology
Dr. Park’s research focuses on the visual system and how the projection neurons in the retina, the retinal ganglion cell axons, find their targets and form synapses in the brain. He is investigating two key areas: 1) cellular and molecular mechanisms underlying the death of neurons and lack of regeneration in the central nervous system after injury and in degenerative diseases like glaucoma and 2) mechanisms by which neurons form proper connections with each other.
Petroll Lab applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and post-docs.
Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.
Pathology
Our lab is studying novel regulatory mechanisms that control innate immunity in intestinal health and disease.
Pediatrics
Chen Lab studies how dysregulation of RNA synthesis and degradation drives childhood cancers with the ultimate goal of identifying new therapeutic vulnerabilities to exploit in treating them.
We are working at the interface of nanotechnology, drug delivery, and tumor immunology.
Pharmacology
Corey Lab is using nucleic acids or nucleic acid mimics to explore important cellular processes, develop novel therapeutic tools and strategies.
Physiology
We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.
The Liu Lab is interested in the functions and mechanism of codon usage biases, circadian clocks, and non-coding RNA.
Radiation Oncology
How do cells sense metabolites to drive their growth and proliferation? We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology.
Reproductive Biology
Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.
Urology
Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.