Medicinal Chemistry Core

Core Mission Statement

The Medicinal Chemistry Core aims to discover and synthesize biologically active small molecules as research tools and drug leads.

Medicinal Chemistry Core Overview

The Medicinal Chemistry Core collaborates with investigators who are interested in using small molecules to test biological hypotheses and to discover new biological processes. Frequently we work closely with the High Throughput Screening (HTS) Core and Pharmacology Core on preclinical drug discovery projects.

Our efforts generally commence after an initial screen has been developed and executed in the HTS core. We work with the biologists and the HTS Core to select the most promising initial hits for further evaluation. We generally focus on 3-5 promising chemical scaffolds and seek to optimize them through iterative chemistry and biological testing. Through the process of chemical optimization, we heavily rely on the Pharmacology group to evaluate metabolic stability, toxicity, in vivo pharmacology, and solubility.

In general, these efforts have two goals: discover a compound suitable for proof-of-concept studies in animals and construct a tool that will facilitate mode-of-action or biochemical studies.

The Medicinal Chemistry Core has contributed to five projects that have been licensed to pharmaceutical companies for further development, as well as numerous patents, publications, and grants.