UT Southwestern embarked on a bold journey into the future of curative medicine by establishing the Viral Vector Core lab and GMP AAV Viral Vector production facility.

Designed to support both internal clinical studies and the wider scientific community, our program has been built around a professional team with diverse expertise, working collaboratively with a broad range of stakeholders.

Our aim is to establish a streamlined, fully equipped viral vector production facility that can provide timely and efficient services to investigators within UT Southwestern and beyond. We are committed to facilitating translational research that applies gene therapy to treat genetic diseases. Our key objective is to deliver high-quality AAV vectors to our diverse client base, including academic institutions, government bodies, foundations, and biotech industry players.

Learn more about the role of AAV Vector Manufacturing in gene therapy.

Mission

Our core mission is to support the research community at UT Southwestern by providing top-tier AAV vectors and associated services for gene therapy translational studies. Our dedicated team of investigators, collaborators, and foundations work tirelessly to bring the future of gene-based medicine into the present.

Vision

Our vision is to be a leading gene therapy program, recognized and respected at local, national, and global levels.

Core Values

• Dedication to patient care
• Honesty
• Transparency in processes
• Innovation
• Commitment
• Efficiency
• Dynamism
• Production Facility

Servicing & Pricing

• Production

  Name	Price
  Plasmid Transfection Ratio Study	Internal: $7,330.00 each UT System/In Network:  $11,000.00 each Commercial/Industry: $14,660.00 each
  250ml-scale research AAV prep (CsCl method)	Inquire
  0.5L-scale research AAV prep	Internal: $1,700.00 each UT System/In Network: $2,550.00 each Commercial/Industry: $3,400.00 each
  1L-scale research AAV prep	Internal: $2,500.00 each UT System/In Network: $3,750.00 each Commercial/Industry: $5,000.00 each
  2L-scale research AAV prep	Internal:  $4,400.00 each UT System/In Network: $6,600.00 each Commercial/Industry:  $8,800.00 each
  5L-scale research AAV prep	Internal:  $9,500.00 each UT System/In Network: $14,250.00 each Commercial/Industry: $19,000.00 each
  10L-scale research AAV prep	Internal: $17,500.00 each UT System/In Network: $26,250.00 each Commercial/Industry: $35,000.00 each
  20L-scale research AAV prep	Internal:  $28,500.00 each UT System/In Network: $57,000.00 each Commercial/Industry: $42,750.00 each
  50L-scale research AAV prep	Internal:  $90,000.00 each UT System/In Network:  $135,000.00 each Commercial/Industry: $180,000.00 each
  50L-scale Tox production lot	Inquire
  500L-scale production lot	Internal:  $950,000.00 each UT System/In Network: $1,425,000.00 each Commercial/Industry: $1,900,000.00 each

• Services

  Name	Price
  Biodistribution qPCR per tier 1 (1-36 samples)>	Internal: $170.00 each
  Biodistribution qPCR per tier 2 (37-72 samples)	Internal: $330.00 each
  Biodistribution qPCR per tier 3 (73-96 samples)	Inquire
  Biodistribution qPCR setup fee (IND-enabling)	Internal:  $750.00 each External: $950.00 each
  Biodistribution qPCR setup fee (standard)	Internal:  $100.00 each External: $200.00 each
  ELISA Testing (VP) 25-32 Samples	Inquire
  Endotoxin	Internal:  $75.00 each
  Potency Testing	Internal:  $5,000.00 each
  Vg Virus Titer (AAV) by qPCR (1-15 Samples)	Internal: $75.00 each
  Vg Virus Titer (AAV) by qPCR (16-36 Samples)	Internal:  $95.00 each

Location

AAV Vector Core is located on the 4th floor of the Green Research Building (Building Y) on UT Southwestern’s south campus. There are separate suites for Process Development, Quality Control (Y4.206), and GMP AAV Viral Vector production (Y4.230).

Leadership

Steven Gray, Ph.D.

Director, Translational Gene Therapy Core (TGTC)

steven.gray@utsouthwestern.edu

214-648-0670

Samer Dahshi, M.S.

TGTC - Operations Manager

samer.dahshi@utsouthwestern.edu

214-648-7164