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2024 Article Archive

Children’s Research Institute at UT Southwestern discovers tumor growth fueled by nucleotide salvage

 

Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children’s Medical Center Research Institute at UT Southwestern published in Cell.

UTSW study identifies RNA molecule that regulates cellular aging

 

A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including neurodegenerative and cardiovascular diseases, diabetes, and cancer, as well as new therapies for a collection of diseases known as ribosomopathies.

UT Southwestern once again ranked best hospital in DFW

 

UT Southwestern Medical Center is the No. 1 hospital in Dallas-Fort Worth for the eighth consecutive year and ranks among the nation’s top hospitals for care in 11 specialties – the most of any hospital in Texas, according to U.S. News & World Report’s annual Best Hospitals list released today.

Sensor involved in regulating metabolic health identified

 

A protein receptor called PAQR4 found within fat cells appears to act as a sensor for ceramides, waxy lipids whose overabundance has been linked to a variety of metabolic disorders and cancers, a study led by UT Southwestern Medical Center researchers suggests.

Sleep apnea sufferers more likely to develop heart disease

 

Obstructive sleep apnea (OSA) is linked to an increased risk of cardiovascular disease in adults, even those younger than 40, researchers at UT Southwestern Medical Center found.

Take summer heat health risks seriously, UTSW experts caution

 

The scorching heat can be inescapable this time of year, and as temperatures hover around triple digits, experts at UT Southwestern Medical Center caution that uncomfortable weather can escalate to dangerous health conditions.

UTSW Research: Female sex hormones, adrenal hyperplasia, and more

 

For decades, researchers have assumed that women taking oral contraceptives have stable levels of sex hormones over each monthly cycle. However, a new study in the American Journal of Physiology-Endocrinology and Metabolism led by Yasin Dhaher, Ph.D., Professor of Physical Medicine & Rehabilitation and Orthopaedic Surgery at UT Southwestern Medical Center, shows that the opposite is true.

Postpartum urinary incontinence linked to mental health

 

A UT Southwestern Medical Center study of hundreds of underserved women showed that depression and anxiety, in addition to physical factors such as a higher body mass index and previous births, are associated with lingering postpartum urinary incontinence. The findings, published in Urogynecology, shine a spotlight on these conditions that can carry stigmas but are largely treatable, researchers say.

Gene-editing nanoparticles correct stem cell mutations in cystic fibrosis models

 

Researchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form for a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.

Electroconvulsive therapy or ketamine? Clinical factors affect outcomes

 

Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows.