Current Research Studies

Dallas 2K

The Dallas 2K study is a long-term study researching the biological mechanisms of depression and antidepressant treatment response. The D2K study is comprised of 2,000 participants, over 10 years of age, with a lifetime or current diagnosis of a mood disorder. Researchers will collect socio-demographic and clinical data, cognitive and psychological assessments, fluid-based biomarkers (blood, urine, saliva), neuroimaging, and EEG. With this information, we hope to create a biosignature to ease treatment selection or identify moderators of response or non-response to treatments in patients with depression. No interventions or treatments will be conducted in the course of the project. Learn more about D2K.


Help us understand more about mental wellness! We are currently recruiting for an exciting new study examining how to develop and foster mental wellness and resilience. The Risk and Resilience Network, a network in UT Southwestern’s Center for Depression Research and Clinical Care, is actively enrolling participants in a study examining adolescents, youths, and young adults (ages 10-24) to uncover the factors that contribute to resilience. No interventions or treatments will be conducted in the course of the project. Learn more about RAD.

Promoting Activity in Cancer Survivors (PACES)

PACES (Promoting Activity Among Cancer Survivors) is a program that seeks to provide education and evidence-based intervention to increase physical activity among breast cancer survivors treated at the Simmons Cancer Center and Parkland Health and Hospital System. Learn more about PACES.

Treatment-Resistant Depression Clinical Trials


The ASCERTAIN –TRD trial is currently recruiting patients to compare three types of treatments for patients with Treatment-Resistant Depression (TRD) who are currently on an antidepressant. Treatments will consist of:

  • Switching antidepressant medications;
  • Adding an additional antidepressant to their current medication;
  • Or adding Transcranial Magnetic Stimulation while they continue their antidepressant medication.

Screening and treatment will last for 8 weeks followed by monthly questionnaires for one year. Participants must be between the ages of 18 and 80 and in a current episode of depression that has lasted for at least 12 weeks, which has not been improved by 2 or more different depression treatments. Sign up to participate in a research study.

Other Research Studies


We are looking for participants between the ages of 18 and 65, who speak English, are not currently taking any antidepressant medication, and are not currently physically active. Eligible participants will be enrolled in a 12-week exercise program consisting of supervised exercise sessions three times per week. Eligible participants may be compensated for their time. Sign up to participate in a research study.

Physical Activity

Do you exercise less than the recommended 150 minutes of physical activity per week? The Center for Depression Research and Clinical Care is currently enrolling participants in a 12-week physical activity program, with weekly group educational sessions, about increasing physical activity in patients with depression. The weekly sessions last 1 hour and participants will be given a Fitbit and access to the CDRC exercise facility for the duration of the study. No compensation is available. Sign up to participate in a research study.

National Drug Abuse Treatment Clinical Trial – Texas Node

National Drug Abuse Treatment Clinical Trial Network – The Clinical Trials Network (CTN) was established in 2000 to bridge the gap between addiction researchers and the clinicians treating addicted patients. The University of Texas Southwestern Medical Center, in joint collaboration with community substance abuse treatment programs in Dallas/Fort Worth, has been awarded a grant by the National Institute on Drug Abuse (NIDA) to participate in this collaborative effort and lead the Texas Node of the initiative.