Amanda Clark, M.D.
Basic Science Award, 2024
What stood out about your research experience at UT Southwestern, and how did it shape your career?
UT Southwestern has one of the biggest concentrations of successful scientists in one place, so it's always easy to find experts when you need help, and forming great collaboration partnerships is commonplace.
How did participating in the Seldin Symposium impact your research path?
The Seldin Symposium gives you good exposure to the vast amount of research happening at UT Southwestern and allows you to meet collaborators. I also got really helpful feedback from some of my poster judges.
What are your current research interests and goals?
My basic research aims to understand how maternal diet and maternal health conditions affect fetal kidney development. The ultimate goal will be to identify nutritional interventions that may optimize fetal kidney development and lifetime kidney health.
What advice would you offer current Internal Medicine trainees about pursuing research?
Consider a research component in your career. Being able to constantly flex the critical thinking part of the brain keeps the work stimulating, and makes clinical care seem more addressable.
Representative Publications
- Cathepsin K cleavage of Angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis.Suzuki T, Loyde E, Chen S, Etzrodt V, Idowu TO, Clark AJ, Saade MC, Flores BM, Lu S, Birrane G, Vemireddy V, Seeliger B, David S, Parikh SM. J Clin Invest. 2025 Mar 3. Epub ahead of print.
- NAD+ metabolism in acute kidney injury and chronic kidney disease transition.Alhumaidi R, Huang H, Saade MC, Clark AJ, Parikh SM. Trends Mol Med. 2025 Jan 4. Epub ahead of print.
- Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.Clark AJ, Saade MC, Vemireddy V, Vu KQ, Flores BM, Etzrodt V, Ciampa EJ, Huang H, Takakura A, Zandi-Nejad K, Zsengellér ZK, Parikh SM. Kidney Int. 2023 Dec. Epub 2023 Sep 30.
- States of quinolinic acid excess in urine: A systematic review of human studies.Saade MC, Clark AJ, Parikh SM. Front Nutr. 2022 Dec 16.
- The Significance of NAD+ Biosynthesis Alterations in Acute Kidney Injury.Clark AJ, Saade MC, Parikh SM. Semin Nephrol. 2022 May. Epub 2022 Nov 18.