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AGING, MEMORY, AND AGING, MEMORY, AND THE BRAINTHE BRAIN Anne M. Lipton, M.D., Anne M. Lipton, M.D., PhPh.D..D. Assistant Professor of Neurology Assistant Professor of Neurology and Psychiatryand Psychiatry UTUT--SouthwesternSouthwestern NORMAL AGING AND THE BRAINNORMAL AGING AND THE BRAIN •• Reduced brain weight and volumeReduced brain weight and volume •• Fewer neuronsFewer neurons •• Widening ofWidening of sulcisulci (grooves)(grooves) •• Enlargement of the ventricular Enlargement of

Adherencia a Medicamento Antidepresivo del Paciente 1. ¿Cuántas veces ha tomado su medicación (o medicamentos) durante la última semana? ____ He tomado mis medicamentos todos los días sin faltar un día. ____ He faltado de tomar mis medicamentos sólo un día. ____ He faltado de tomar mis medicamentos sólo dos días. ____ He faltado de tomar mis medicamentos por tres o cuatro días. ____ He faltado de tomar mis medicamentos por cinco o más días. ____ He dejado de

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Intracellular Protein Degradation and the Ubiquitin-Proteasome System George N. DeMartino ND12.124 214. 645.6024 george.demartino@utsouthwestern.edu Presenter Presentation Notes We will see how protein degradation in general, mediated by the ubiquitin-proteasome pathway in particular, regulates many important physiological functions and how disfunction of this activity leads to a number of pathological states.  The basics General features of intracellular protein

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Kathleen Bell, MD Sometimes if you pro- crastinate, life pre- sents you with inspira- tion. Waiting until just the last minute to write this column pre- sented me with just that sort of opportunity. I returned today from the AAPMR Annual As- sembly in New Orleans. It is, to a large degree, a professional family reunion. On a personal level, I am thrilled to see some of my teachers still attending and particularly, to see my for- mer residents and students. At one point dur

Anti-malarial Drug Discovery Jeffrey Baldwin, PhD UT Southwestern Medical Center Department of Pharmacology Malaria Burden Life Cycle Jones & Good, Nature Medicine (Feb. 2006) Complex life cycle Intracellular parasite Pathogenesis 4 Plasmodium species are human pathogens: Falciparum Vivax Ovale Malariae Miller et al, Nature (7 Feb, 2002) Clinical Outcomes Miller et al, Nature (7 Feb, 2002) Immune Evasion PfEMP1 is key to lethality of P. falciparum Sticky molecules evade

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by James de Lemos, M.D. In the medical world, a lot has happened over the past 10 years. But one of the most significant events in the Dallas/Fort Worth Metroplex, and perhaps the most far-reaching, has been the start-up and ongoing work of a major heart study conducted at UT Southwestern Medical Center (UTSW). The early results of that study are transforming cardiovascular risk factor identification and management for UTSW physicians and leading to better care for patients. In 1999