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Overview of Gastrointestinal Function George N. DeMartino, Ph.D. Department of Physiology University of Texas Southwestern Medical Center Dallas, TX 75390 The gastrointestinal system Functions of the gastrointestinal system • Digestion • Absorption • Secretion • Motility • Immune surveillance and tolerance GI-OP-13 Histology of the GI tract Blood or Serosal Side Lumenal or Mucosal Side Structure of a villus Villus Lamina propria X X X X X Lumen

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Protein Structure Determination An Introduction Chad A. Brautigam, Ph.D. Structural Biology Laboratory UTSW Medical Center at Dallas What is “Protein Structure?” …Arg-Lys-Ala-Gln-Trp-Cys-His-Ala-Asp… What is “Protein Structure?” • It is the description of the three- dimensional architecture of a polypeptide. • Our aim: to know accurately and precisely the position of every atom in a protein. That’s usually between 2000 and 10,000 atoms! Wherefore Art Thou, Protein

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Once Upon a Time NGS UTSW NGS Lab Requisition ORDER INSTRUCTIONS PRINCIPAL INVESTIGATOR INFORMATION GERMLINE TISSUE UTSW LAB USE ONLY Collection Status Tumor collected prior to day of order placement Tumor collected on day of order placement TUMOR TISSUE Study Specimen Identifier: ICD-10-CM: Tumor Collection Date: (mm/dd/yyyy) ____/____/________ Tissue: Blood (must collect FRESH) Bone Marrow (may collect fresh) Other: ______________________________ Germline