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\ PEGSITACIANINE FOR THE SURGICAL DETECTION OF HEAD AND NECK CANCER PURPOSE INCLUSION DESIGN To investigate whether Pegsitacianine a fluorescent nanoparticle can image head and neck cancer and unknown primary head and neck cancer during surgery or biopsy. 1. Adults ≥ 18 years of age 2. Patients with stage 1-4 Head and Neck Squamous Cell Carcinoma (HNSCC) undergoing surgical excision 1. Phase 2 Clinical trial of Pegsitacianine, which is

Theranostics 2020, Vol. 10, Issue 7 http://www.thno.org 3340 Theranostics 2020; 10(7): 3340-3350. doi: 10.7150/thno.41239 Research Paper Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles Zachary T. Bennett1, Qiang Feng1, Justin A. Bishop2, Gang Huang1, Baran D. Sumer3, and Jinming Gao1,3 1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 2

Zhongzheng (Brooks) Fu, Ph.D. Last updated: September, 2023 ORCID: 0000-0002-2572-6284 Email: zhongzheng.fu@utsouthwestern.edu Website: zfu-lab.org 5323 Harry Hines Blvd, MC 8855 Dallas, TX 75390 United States Academic Positions 2023 – on Assistant Professor Department of Neurological Surgery UT Southwestern Medical Center Dallas, TX, USA 2023 – on Visiting Scholar Division of the Humanities and Social Sciences California Institute of Technology Pasadena, CA, USA Postdoctoral Trainings

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Single Cell Transcriptomics – a simple walkthrough Adwait Sathe, PhD McDermott Center Bioinformatics Lab adwait.sathe@utsouthwestern.edu MCDERMOTT CENTER BIOINFORMATICS LAB 1 mailto:Adwait.sathe@utsouthwestern.edu RNASeq RNASeq 2 MCDERMOTT CENTER BIOINFORMATICS LAB https://www.10xgenomics.com/solutions/single-cell/ Single cell RNA Sequencing Workflow Dissociation of solid tissue Isolate single cells DROP-Seq, Smart-Seq etc. RNA cDNA Amplified RNA Amplified cDNA Sequencing

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1 Ready; Catalysis Kinetics-1 There are only two important things in chemistry, kinetics and thermodynamics. And, exp(-ΔG/RT) = k1/k-1, so there’s really only one thing. Kinetics provides information about the transition state of a reaction. We’ll use a simple example to learn the basic tools, then look at more applications to catalysis. Crude Data [EtI] = [NaCN] 0 0.2 0.4 0.6 0.8 1 1.2 0 2 4 6 8 10 Time Co nc en tra tio n [EtI] [EtCN] 1st step

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Ready; Catalysis Nonlinear Effects Outline Definitions Origins of nonlinear effects in enantioselective reactions ML2 model Reservoir model Transition-state model Kinetic aspects of nonlinear effects Asymmetric amplification Cool tricks Origin of biotic asymmetry? Key reviews Kagan, ACIEE, 1998, 2922 (a pretty complete review, source of many of my figures) Kagan, Advanced Syn. Cat., 2001, 227 (an overview) Blackmond, Accts, 2000, 402 (kinetic aspects) Soai

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