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Zeiss LSM780 Upright (ND5.740) Upright confocal microscope configured for organ culture and whole animal imaging Visible laser lines 405, 458, 488, 514, 561, 594, 633 nm. Coherent Vision II laser for two-photon imaging and SHG Spectral detection with ultrasensitive GaAsP detector Two non-descanned detectors for deep imaging Objectives: 10x (NA 0.3 and 0.45), 20x (NA 0.8 and 1), 32x (NA 0.85), 40x (NA 1.1 and 1.3), 63x (NA 1.4) Motorized stage Temperature control Sign Up Back-to top

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

The Cyclotron and Radiochemistry Program facility encompasses a General Electric PETtrace Cyclotron, a current Good Manufacturing Practice clinical production laboratory.

Physiology: Advanced Phenotype Capabilities We offer cutting-edge phenotyping capabilities to provide detailed physiological assessments. This enables precise characterization of patient populations, facilitating personalized management approaches for enhancing the accuracy of clinical trials. Tests offered: Cardiopulmonary Exercise Testing (CPET): A comprehensive assessment of cardiovascular and respiratory function performed using a stationary bicycle ergometer. This test measures key

The Cyclotron and Radiochemistry Program at UT Southwestern is divided into two cores: Adult and Pediatric.

Zeiss LSM980 Airyscan2 (NL5.120LA) For conventional and superresolution confocal microscopy of immunofluorescent cell cultures and tissue sections. 405, 445, 488, 514, 561, 594, 639 and 730nm laser lines AI sample finder for automatic sample detection and tiling Fast xy-stage for multi-point acquisition and tiling. High speed piezo z-stage with 500 micrometer travel Perfect Focus System to keep your sample in focus Spectral detector 32 channels GaAsP PMT plus 2 channels MA-PMT Transmitted light

Glycosylation Introduction Glycosylation can be a very challenging PTM to analyze by mass spectrometry, in large part because of the multiple different sequences a glycan can have on a single site. Additionally, the glycan on a peptide can easily fall off in the mass spectrometer, making sequencing and localization challenging. However, with the Oribtrap Fusion Lumos and its capabilities to perform electron transfer dissociation (ETD) along with higher-energy collisional dissociation (HCD), we

Instrumentation The core is equipped with seven mass-spectrometry platforms to provide a wide range of analyses to customers and collaborators. These instruments are housed in a purpose-built access-controlled facility with dedicated HVAC, and many power and network connections. This facility provides ample space and flexibility for future growth and instrument developments. Shotgun Proteomics Thermo Orbitrap Eclipse – This mass spectrometer was acquired by the core in 2022. The Eclipse is among