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Data Management Our computers are not intended for storage, only for data acquisition, and we are not responsible for your data! Data must be backed up at the end of each session to a storage location managed by the user! To provide enough storage for new data, we reserve the right to delete older data from our computers without warning. The user data folders on all our computers are accessible via the campus LAN. Off-campus access to these computers requires a VPN connection ( VPN access ). To

News from the Center for Organogenesis, Regeneration and Trauma at UT Southwestern.

As a crucial part of the clinical research process to develop new treatments, improve diagnosis, and help prevent diseases, UT Southwestern conducts clinical studies and clinical trials.

UT Southwestern fosters a rich collaboration among biostatisticians, epidemiologists, bioinformaticians, computer programmers, and database experts that supports clinical research projects.

Anatomic Pathology The Histo Pathology Core offers anatomic pathology services on an as needed basis to train clients as well as facilitate morphologic and histologic endpoints in large terminal studies with mice. The Core provides expert training in the following procedures with mice: Transcardial Whole Body Perfusion All Organs Survey Dissection Organ Specific Dissection Organ Specific Grossing Embryo Collection and Staging (E8 - E15) The Core maintains animal use protocols covering the

Aqueous Solubility Determination Poor aqueous solubility can limit the ability to develop lead compounds as in vivo probes and therapeutics. Aqueous solubility affects absorption, formulation and ability of a compound to be delivered in sufficient concentrations to be active, and even in vitro activity. The Core offers two types of assays: Thermodynamic (or Equilibrium) Solubility Measures solubility of a compound as a saturated solution in equilibrium. Solubility can be dependent on pH and the

Special Stains The Histo Pathology Core offers a wide menu of special stains for improving visualization of normal and disease state chemical moieties. Special Stains that the Core performs on a routine schedule include Oil Red-O stain for neutral lipids, Masson's Trichrome stain for collagen/fibrosis, Periodic-Acid Schiff for sugars and basement membrane, as well as Hart's variation of the Verhoeff Van Gieson's technique for elastin. Optimum staining for some substances requires a specific

Specialized Techniques The Histo Pathology Core offers services that are irregular offshoots of histology, and usually only performed in individual academic or pharmaceutical research lab settings. Services, such as Laser Microdissection and others listed on this page, are technically demanding and somewhat slow throughput, but are of great interest to select clients. The Core created this separate page as a catch-all for these service offerings that are not easily characterized within any of

ChIP-Seq Libraries from 5–10 ng ChIP DNA are prepared using KAPA HTP Library Preparation Kit. The ChIP DNA is quantified on the Qubit® 2.0 Fluorometer from Invitrogen Samples are end repaired, 3' ends adenylated and barcoded with mµltiplex adapters. PCR amplified libraries are purified with Ampure XP beads, then checked on the Agilent 2100 Bioanalyzer to ensure the library is the expected size. Samples are quantified by Qubit before being normalized and pooled, then run on the Illumina HiSeq

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.