Critical Anatomy/ISH The Histo Pathology Core is based upon the premise that research-oriented histology is about meeting the client investigators' need for critical anatomy. The lab is well versed in: Performing dark-field assisted cut-and-look microtomy to meet comparative anatomy between specimens. Matching specific sectioning planes to Kaufman mouse embryo or Paxinos brain anatomy atlases. Matching sectioning planes to previously cut slides or anatomy depicted in journal articles. Achieving

Each of the six funded centers nationwide is comprised of research projects and core facilities with an emphasis on translational and clinical research for various muscular dystrophies.

Anatomic Pathology The Histo Pathology Core offers anatomic pathology services on an as needed basis to train clients as well as facilitate morphologic and histologic endpoints in large terminal studies with mice. The Core provides expert training in the following procedures with mice: Transcardial Whole Body Perfusion All Organs Survey Dissection Organ Specific Dissection Organ Specific Grossing Embryo Collection and Staging (E8 - E15) The Core maintains animal use protocols covering the

Special Stains The Histo Pathology Core offers a wide menu of special stains for improving visualization of normal and disease state chemical moieties. Special Stains that the Core performs on a routine schedule include Oil Red-O stain for neutral lipids, Masson's Trichrome stain for collagen/fibrosis, Periodic-Acid Schiff for sugars and basement membrane, as well as Hart's variation of the Verhoeff Van Gieson's technique for elastin. Optimum staining for some substances requires a specific

Specialized Techniques The Histo Pathology Core offers services that are irregular offshoots of histology, and usually only performed in individual academic or pharmaceutical research lab settings. Services, such as Laser Microdissection and others listed on this page, are technically demanding and somewhat slow throughput, but are of great interest to select clients. The Core created this separate page as a catch-all for these service offerings that are not easily characterized within any of

Genaro Hernandez, Ph.D., a postdoctoral scholar, is profiled in a look at his research in human pseudokinases in the PROVIDES program at UT Southwestern.

A profile on Sergio Cepeda, who researches Vitamin A as a PROVIDES postdoctoral scholar at UT Southwestern.

The Metabolomics Core Facility focuses on targeted metabolomics (quantitation and validation) and untargeted metabolomics (discovery of metabolites).

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.

View career openings at the Center for Regenerative Science and Medicine at UT Southwestern in Dallas, TX.