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Whole Brain Microscopy Equipment The WBMF offers access to a unique set of high-throughput microscopes and histology resources, ideal for collecting high-content neuroscience data, for UT Southwestern and external researchers. Please remember to acknowledge your usage of our facility resources in your publications using our established Research Resource Identifier code anywhere in your methods or acknowledgements: RRID: SCR_017949 . This is critical for us to maintain support for the core. Jump

Whole Brain Microscopy Services & Fees 3D Volumetric Imaging and Automated Analysis We can generate high-resolution, whole-brain/whole-tissue 3D images as a full-service operation using serial two-photon tomography (STPT) or lightsheet microscopy according to specific experimental needs. Fixed specimens can be provided to the core, and we can take it from there. Core staff can perform STPT or tissue clearing using the Clear+ method, whole-brain/whole-tissue immunostaining, and lightsheet

There are sample requirements for services provided by Sanger Sequencing Core, McDermott Center. Standard primers are provided.

Determination of Intracellular Compound Concentrations Occasionally large differences in compound potency in biochemical versus cell-based assays are noted. While protein binding may account for some of this discrepancy, we have on occasion noted differences in the extent to which different compounds accumulate inside of cells or the extent to which the same compound accumulates in different cells (1). We have developed an intracellular compound accumulation assay to measure the amount of

Nikon Widefield Epi-scope (NL5.120R) Inverted Nikon EclipseTi with high-quality optics for widefield epifluorescence in fixed and live cells Motorized xy-stage for multi-point acquisition and tiling. Perfect Focus System to keep your sample in focus Excitation filters centered around 350, 405, 445, 488, 514, 555 and 645 nm 10x, 20x, 40x, 60x and 100x objectives with phase or DIC available Andor Zyla 5.5 sCMOS with large 2560x2160px field of view for fluorescence Teledyne Infinity3-6UR color

Dr. Daniela Nicastro has stepped down as Director of the Cryo-EM Facility at UT Southwestern.

Master Agreements are agreements that embody agreed-upon terms and conditions of a basic relationship between the University and a sponsor.

UT Southwestern offers scholar funding programs that provide financial resources, career guidance, and protected research time to facilitate the early career development of physician-scientists who have high potential to conduct clinical research and advance research science.

Faculty Resources Employee Resources Human Research Protection Program Micro Navigation UTSW IRB sIRB Participants QA/Monitoring Regulatory Support Reportable Events News UTSW Serving as the sIRB Relying on External sIRB sIRB Definitions Relying on External sIRB UTSW Human Research Protection Program (HRPP) supports the requirement for single IRB review by collaborating with multiple External IRBs. Start-up Process to use External IRB An overview of the start-up process to use an External IRB is

Our standardized protocols ensure reproducibility and high-quality results for researchers