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Structural Biology Lab provides helpful resources such as protocols for equipement setup and use, protein handling tips, and videos.

Equipment in the Structural Biology Lab of Core Facilities includes robotic crystal sample handling, automatic plunge freezing, crystallization tray setup, X-ray generators, cryo-electron microscopes, and high-resolution SEM coating systems.

Directory Jay Horton, M.D. Managing Director Project: Administrative Core UTSWNORC@UTSouthwestern.edu Joel Elmquist, D.V.M., Ph.D. Director Pilot & Feasibility Core Joel.Elmquist@UTSouthwestern.edu Joyce Repa, PhD Co-Director Pilot & Feasibility Core Joyce.Repa@UTSouthwestern.edu Jeffrey Zigman, M.D., Ph.D. Director Enrichment Program Jeffrey.Zigman@UTSouthwestern.edu Philipp Scherer, Ph.D. Director Animal Phenotyping Core Philipp.Scherer@UTSouthwestern.edu Jeffrey McDonald, Ph.D. Director Lipid

Animal Phenotyping/Metabolism Core Example of one of our services we offer to our NORC investigators on a Seahorse instrument Mitochondrial Respiratory Profile. Oxygen-consumption in live-cells in response to basal conditions (glucose and pyruvate), oligomycin (ATP synthase inhibitor), FCCP (chemical uncoupler), and antimycin-A (complex III inhibitor). The Metabolic Phenotyping Core (MPC) provides state-of-the-art analytical and phenotypical measures to the scientific community both inside and

Pilot and Feasibility Program Awardees 2024 Pilot & Feasibility Grant Awardees Amanda Casey, Ph.D. Assistant Professor Renewal The Role of Fic-mediated AMPylation in Metabolic Disease Dr. Casey will study the role of cell stress pathways in cells that regulate metabolism during the course of diet-induced obesity. She will use a novel genetically modified mouse model to investigate the role of cell stress in several key tissues regulating blood glucose levels and whole-body metabolism

Read NORC News & Announcements

The DNA Genotyping Core facility performs allelic discrimination using an Applied Biosystems 7900HT real-time PCR instrument and the TaqMan Assay.

News on Women's Health research at UT Southwestern

AAV Viral Vector Core Facility was designed to support both internal clinical studies and the wider scientific community, our program has been built around a professional team with diverse expertise, working collaboratively with a broad range of stakeholders.

The Biomarker Research Core (BRC) is focused on supporting investigator-initiated cancer clinical trials.