Mutations in a gene called OTP cause obesity by controlling the output of another gene already targeted by an anti-obesity drug, a study led by UT Southwestern Medical Center researchers shows.

Former college athletes with a history of concussions were more likely to perceive themselves as cognitively impaired later in life if they had mood disorders such as depression and anxiety – even when testing showed no such decline in mental acuity, a study from UT Southwestern Medical Center

– Arlette Chavez was a typical 3-year-old who loved jumping on the bed, riding her bike, and playing tag, said her mother, Lesly Rivera. When this active preschooler started complaining of pain in her left arm, Ms. Rivera and her husband, Carlos Chavez, weren’t overly concerned – it was probably a

Javier Garcia Bermudez, Ph.D., an Assistant Professor in Children’s Medical Center Research Institute at UT Southwestern (CRI), is one of 67 scientists awarded a 2024 National Institutes of Health High-Risk, High-Reward Research grant.

As a young man in his mid-20s, Jorge Gómez was one of thousands of Cuban citizens who fled communism and the island country on a raft in 1994. He would spend 11 months living in a tent city at Guantanamo Bay before being granted asylum in the U.S., where he overcame numerous obstacles to build a

Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

Scientists with UT Southwestern’s Peter O’Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication.

Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children’s Medical Center Research Institute at UT Southwestern published in Cell.

A genetic marker discovered by UT Southwestern Medical Center researchers could help physicians predict which patients with hepatocellular carcinoma are most likely to develop resistance to the drug lenvatinib. The finding, published in the journal Gastroenterology, may lead to alternative

Tears or ruptures of the ulnar collateral ligament (UCL) are the most common elbow injury among baseball players from youth leagues to the major leagues, especially pitchers.