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An increased concentration of the hormone leptin in fat cells is believed to be responsible for weight gain associated with antipsychotic drugs.

Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows.

A study of mutant models of fragile X syndrome (FXS), a genetic disorder related to autism and intellectual disability, shows that activation of the cerebellum mitigates aberrant responses in sensory processing areas of the brain and improves neurodevelopmental behaviors.

Researchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form for a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.

Nutritious meal kits and no-prep meals improved food security and perceived dietary quality among clients of a Dallas food pantry, according to a pilot study led by UT Southwestern Medical Center.

Proteins known as oligomeric chaperones help suppress the formation of misshaped proteins that cause a variety of degenerative and neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s.

Caring for someone with dementia or Alzheimer’s disease is challenging. In addition to the financial and physical demands, many caregivers are unprepared for the stress of trying to effectively communicate with a loved one who may be prone to agitation, verbal aggression, and hallucinations.

Total knee replacements performed with the help of a surgical robot have better outcomes on average than similar surgeries performed manually but can cost significantly more, a new study by UT Southwestern Medical Center researchers shows.

Children’s HealthSM and UT Southwestern Medical Center unveiled plans for a new $5 billion pediatric health campus in Dallas’ Southwestern Medical District today. Spanning more than 33 acres, the new pediatric campus offers a patient-centric design that can meet the rapidly increasing need for more pediatric services ranging from the most common to the most complex.

UT Southwestern Medical Center has joined an elite Honor Roll of the nation’s top 20 hospitals recognized for delivering the highest standard of care, according to U.S. News & World Report’s Best Hospitals listings for 2023-24