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The National Cancer Institute (NCI) has renewed UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center Kidney Cancer Program (KCP) Specialized Program of Research Excellence (SPORE) award.

The human heart is an intricate, complex organ and, like a car that starts sputtering, its function deteriorates for all sorts of reasons.

Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD) models, UT Southwestern researchers reported.

Leveraging its broad expertise in biomedical informatics, data sciences, and clinical sciences, UT Southwestern Medical Center is aggressively expanding its involvement in clinical informatics, which aims to harness the power of big data to improve patient care and public health.

Following Enhanced Recovery After Surgery (ERAS) protocols designed to minimize surgical stress results in improved patient recovery and satisfaction, reduced postoperative complications, and shorter hospital stays, according to a review of ERAS programs in minimally invasive gynecologic surgery by UT Southwestern researchers.

The earlier individuals develop Type 2 diabetes or hypertension in life, the earlier they are likely to develop primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, researchers from UT Southwestern reported in a recent study.

UT Southwestern researchers have identified a molecular pathway responsible for the spread of glioblastoma to surrounding tissue in the brain, as well as an existing drug that curbed tumor growth in animal models.

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA’s regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

In just a few hours, UT Southwestern scientists can tell which variant has infected a COVID-19 patient – a critical task that can potentially influence treatment decisions but takes days or weeks at most medical centers.

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.