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PTM Identification Introduction The presence or absence of post-translational modifications (PTMs), such as phosphorylation, on a protein are often as interesting as the presence of absence of the protein itself. The PTM ID service offers identification of PTMs on a protein from a purified protein or…

Publications and Expertise The staff of the proteomics core work closely with customers, and are often heavily involved in the write-up process of projects that have made use of mass spectrometry services. In addition to our co-authored papers, our work is frequently acknowledged by our researchers i…

Silac Quantitation Introduction Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) is a powerful technique for comparing protein (and peptide) amounts between two or three conditions. Developed in the lab of Matthias Mann it is one of the most widely used labeled quantitation methods in p…

TMT Quantitation Introduction Tandem Mass Tag (TMT) technology is a powerful technique for comparing protein (and peptide) amounts between six to eighteen conditions. This technique involves labeling samples after digestion, meaning this technique can be used on in vivo samples, unlike SILAC. TMT or …

CMRU Core Offerings: Wet Lab Our state-of-the-art wet lab is equipped with specialized analytical tools and technologies, such as the Cobas e411 and Cobas c311 modules. These capabilities allow us to perform a wide array of diagnostic tests, from biochemical panels to drug screening, ensuring precise…

In Memoriam: Scott Grundy Published on: January 31, 2025 Scott M. Grundy, M.D., Ph.D. Scott M. Grundy, M.D., Ph.D. , Professor in the Center for Human Nutrition and in the Department of Internal Medicine, died on Wednesday, Jan. 29. He was 91. In 1981, Dr. Grundy joined UT Southwestern as founding Di…

Zigman Receives Prestigious Founders Award from The Obesity Society Published on: October 22, 2024 Jeffrey Zigman, M.D., Ph.D., FTOS , a Professor of Internal Medicine and Psychiatry, has received The Obesity Society’s George A. Bray Founders Award . This prestigious honor acknowledges his significan…

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.

Expert Clinical Research Team Our team of seasoned clinician-scientists brings extensive expertise and dedication to advancing medical research. Collaborating with large institutions such as Parkland Hospital and UT Southwestern Medical Center, we have access to dedicated clinical patient cohorts, en…

Levi Lab cell lines.