Research Studies

The ADC will be starting several new studies in the next few months. Please check our site for updates about our studies and/or leave your contact information on the Join a Study page.

To learn more about studies underway, scroll down for more information or call the UT Southwestern Memory Research Unit at 214-648-0563.

Study participants like Dewayne Nash, M.D., (see video below) have found that participating in our clinical trials has helped him in ways he never expected.

Clinical Trials

PROGRESS OF MILD ALZHEIMER'S DISEASE IN PARTICIPANTS ON SOLANEZUMAB VERSUS PLACEBO – Now enrolling
Sponsor: Eli Lilly
Seeking men and women aged 55 to 90 years with a diagnosis of mild Alzheimer's. The purpose of this study will be to test the idea that Solanezumab will slow the cognitive and functional decline of Alzheimer’s disease (AD) as compared with placebo in participants with mild AD. Subjects must have a “study partner” accompany them to each visit and be available by phone. The length of the study is about 18 months. To qualify, a subject must meet certain inclusion and exclusion criteria. For more specific information about this study, please contact the study coordinator, Kathy Koch at 214-648-9343 or email kathleen.koch@utsouthwestern.edu.

EXERCISE
People with mild cognitive impair­ment who do not currently adhere to a regular fitness program are needed for a one-year study that will compare individually tailored, supervised aerobic exercise training with flexibility and stretching training. The trial researchers will investigate the effects of exercise on cognitive and cardiovascular health, as well as changes in proteins known to damage and/or protect the brain. Call Zohre German at 214-648-2952 or Candace Hill at 214-345-4665 for information.

COGNITIVE TRAINING FOR MILD MEMORY COMPLAINTS
People aged 60 or older who are in overall good health but who are noticing more “senior moments” or have been diagnosed with mild cognitive impairment are needed for a study evaluating the effects of cognitive training on brain function. A brief cognitive screening will be given to determine eligibility for the study. Those who qualify will receive eight cognitive training sessions, study-related assessments, an electroencephalogram to measure brain waves, and follow-up testing. For more information, call Audette Rackley at 214-905-3007.

Observational and Biomarker Development Studies

While these studies do not require or offer a new treatment, they are the foundation for future research and therapeutic trials

ADNI 2 (ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE – PHASE 2)
This study builds on the first ADNI studies. At this point the study is enrolling people ages 55 to 90 who have memory complaints but are without impairment on cognitive testing. Participants will undergo magnetic resonance imaging (MRI), traditional glucose-based positron emission tomography (PET), new amyloid PET scanning to investigate the formation of beta-amyloid plaque formation, and standard neuropsychological and neurological exams. Participants will be compensated for their time and participation. Call Jackie Rabb, 214-648-9358.

CORE AND TARCC RESEARCH STUDIES
People with mild cognitive impairment, early Alzheimer’s disease, or frontotemporal dementia are needed for observational studies. The studies usually involve one visit a year for neuropsychological testing, neurological exams, brain imaging, and blood sampling. The data collected from these visits are used by many investigators studying the aging brain and disorders of cognitive function. These visits often involve financial compensation. Call Sarah Hoefs at 214-648-0563. Click here for more information about TARCC.

LOAD (LATE-ONSET ALZHEIMER’S DISEASE GENETICS INITIATIVE)
The LOAD study originally began enrolling subjects in 2002, with more than 500 subjects enrolled through UT Southwestern! A new grant based on previous findings from that study is offering a phone follow-up contact for subjects from the first study as well as enrolling new subjects. The goal of this national study is to expand upon the scope of information/data gathered from subjects already enrolled in the first phase of LOAD as well as to enroll new large families (with three or more living siblings age 60 or older) diagnosed with Alzheimer’s disease (AD). The focus is to learn more about the genetic, environmental, and health risks that may contribute to the development of AD. For all subjects previously enrolled in the LOAD study, the coordinator will call each person for phone follow-up only. New subjects from previously participating families who are now age 60 or older may also enroll in this study. Call Barb Davis at 214-648-9367.