Welcome to Research

As one of the world’s foremost research institutions, The University of Texas Southwestern Medical Center™ fosters “no-fence” multidisciplinary research and rigorous scientific training in both basic and clinical research. UT Southwestern has a superb international reputation for life-changing research that has led to some of the most important discoveries of our generation, including the life-saving statin drugs. Our discoveries make a difference.

Scientific Discoveries

UT Southwestern Medical Center is home to many nationally and internationally recognized physicians and scientists, including five Nobel Laureates, 18 members of the National Academy of Sciences, and 18 members of the Institute of Medicine, a highly esteemed component of the NAS. Faculty members’ investigations, ranging from the microscopic level to patient care as a whole, continue to bring about notable discoveries, important educational opportunities, and advanced treatment options for improved health care.

Distinguished Faculty

  • 1985 Nobel Prize in Physiology or Medicine

    Dr. Michael Brown, Dr. Joseph Goldstein

  • 1988 Nobel Prize in Chemistry

    Dr. Johann Deisenhofer

  • 1994 Nobel Prize in Physiology or Medicine

    Dr. Alfred Gilman

  • 2011 Nobel Prize in Physiology or Medicine

    Dr. Bruce A. Beutler

Home to many nationally and internationally recognized physicians and scientists, UT Southwestern Medical Center's faculty has many distinguished members including five Nobel Laureates since 1985, 18 members of the National Academy of Sciences (NAS), and 18 members of the Institute of Medicine, a component of the NAS.

Research Areas

Photo of lab research testsOur clinical research includes the groundbreaking Dallas Heart Study. The DHS involved more than 6,000 ethnically diverse participants in Dallas County. UT Southwestern researchers found, among other results, rare variants of a gene responsible for reduced levels of low-density lipoprotein cholesterol (LDL-C) among African-Americans. Further research showed that moderate decreases in LDL-C, early in life, could have a greatly beneficial effect on cardiovascular disease.

Basic research efforts include investigation of the molecular control of circadian rhythms, embryonic development, reproduction, and protein structure.

UT Southwestern also supports translational research – “bench to bedside” research that quickly moves basic discoveries into clinical trials that directly benefit patients. For instance, small artificial molecules called peptoids show promise as both diagnostic tools and treatments for various types of cancer. Peptoids can bind to cancerous cells more tightly than normal cells. Researchers are looking at ways to combine peptoids with anti-cancer drugs to target cancer cells more specifically.

Vast Funding Sources

Funding from federal agencies, foundations, companies and private donors provide more than $417 million per year to fund about 3,500 research projects.