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Current Research Studies

Dallas 2K

The Dallas 2K study is a long-term study researching the biological mechanisms of depression and antidepressant treatment response. The D2K study is comprised of 2,000 participants, over 10 years of age, with a lifetime or current diagnosis of a mood disorder. Researchers will collect socio-demographic and clinical data, cognitive and psychological assessments, fluid-based biomarkers (blood, urine, saliva), neuroimaging, and EEG. With this information, we hope to create a biosignature to ease treatment selection or identify moderators of response or non-response to treatments in patients with depression. No interventions or treatments will be conducted in the course of the project. Learn more about D2K.


Help us understand more about mental wellness! We are currently recruiting for an exciting new study examining how to develop and foster mental wellness and resilience. The Risk and Resilience Network, a network in UT Southwestern’s Center for Depression Research and Clinical Care, is actively enrolling participants in a study examining adolescents, youths, and young adults (ages 10-24) to uncover the factors that contribute to resilience. No interventions or treatments will be conducted in the course of the project. Learn more about RAD.


This is a new innovative study to help patients find the right antidepressant for them. We are testing whether a simple blood test can predict whether an individual patient does better between two antidepressants: escitalopram and bupropion. Our goal is that, according to the patient’s unique biology, they can be matched with the right antidepressant without trying the wrong one first. Simply put, we want help people get better faster. To be eligible, participants must not currently be treating their depression with medication and be willing to start medication. Sign up to participate in a research study.

Treatment-Resistant Depression Clinical Trial


The ASCERTAIN –TRD trial is currently recruiting patients to compare three types of treatments for patients with Treatment-Resistant Depression (TRD) who are currently on an antidepressant. Treatments will consist of:

  • Switching antidepressant medications;
  • Adding an additional antidepressant to their current medication;
  • Or adding Transcranial Magnetic Stimulation while they continue their antidepressant medication.

Screening and treatment will last for eight weeks followed by monthly questionnaires for one year. Participants must be between the ages of 18 and 80 and in a current episode of depression that has lasted for at least 12 weeks, which has not been improved by two or more different depression treatments. Sign up to participate in a research study.

Bipolar Study

Bipolar disorder affects the whole family, and early detection is key when it comes to preventing or treating it. This study involves boys and girls ages 15-25 who have a parent living with bipolar disorder in a groundbreaking study that is seeking to understand the factors that lead to this disease and enhance treatment for future generations. Eligible participants are monitored over a 24-month period and take part in clinic visits, phone calls, and weekly questionnaires. With this information, we hope to change the future of bipolar disorder. This study is no longer enrolling new participants.


Ever wonder how depression affects your memory and thinking skills? The CDRC is conducting a study comparing the reliability of self-administered memory and thinking skills tests taken on an iPad tablet against the same tests administered by a doctor. Individuals who are currently taking an antidepressant and responding well to treatment are eligible for this study and could help us test a new app that measures thinking and memory skills. All study-related evaluations and care are provided at no cost, and participants may be eligible for compensation. This study is no longer enrolling new participants.

Promoting Activity in Cancer Survivors (PACES)

PACES (Promoting Activity Among Cancer Survivors) is a program that seeks to provide education and evidence-based intervention to increase physical activity among breast cancer survivors treated at the Simmons Cancer Center and Parkland Health and Hospital System. Learn more about PACES.


Other Research Studies


We are looking for participants between the ages of 18 and 65, who speak English, are not currently taking any antidepressant medication, and are not currently physically active. Eligible participants will be enrolled in a 12-week exercise program consisting of supervised exercise sessions three times per week. Eligible participants may be compensated for their time. Sign up to participate in a research study.

Physical Activity

Do you exercise less than the recommended 150 minutes of physical activity per week? The Center for Depression Research and Clinical Care is currently enrolling participants in a 12-week physical activity program, with weekly group educational sessions, about increasing physical activity in patients with depression. The weekly sessions last one hour and participants will be given a Fitbit and access to the CDRC exercise facility for the duration of the study. No compensation is available. Sign up to participate in a research study.

National Drug Abuse Treatment Clinical Trial – Texas Node

National Drug Abuse Treatment Clinical Trial Network – The Clinical Trials Network (CTN) was established in 2000 to bridge the gap between addiction researchers and the clinicians treating addicted patients. The University of Texas Southwestern Medical Center, in joint collaboration with community substance abuse treatment programs in Dallas/Fort Worth, has been awarded a grant by the National Institute on Drug Abuse (NIDA) to participate in this collaborative effort and lead the Texas Node of the initiative.