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Myoediting Core/Duchenne Skipper Database

The UT Southwestern Wellstone Myoediting Core will provide a unique, efficient, cost-effective, and collaborative molecular biology resource to be shared by the entire Wellstone Network. Focusing on DMD, the Wellstone Myoediting Core will provide an immediately accessible resource for Wellstone Network physicians and scientists to obtain CRISPR/Cas9 myoediting tools, technology and expertise to functionally rescue dystrophin expression in their own patient’s cells grown as iPSC-derived “DMD-in-a-dish” skeletal and cardiac muscle cell cultures.

UTSW Wellstone Myoediting Core Cell Line List

Line NameTypeMutationCell Type
TX1 DMD T->G EX47A iPSC
TX2 DMD DEL EX49-52 iPSC
TX3 DMD DEL EX44 iPSC
TX4 DMD INS EX55-59 iPSC
TX5 DMD N/A PBMC
TX6 DMD N/A PBMC
TX7 DMD INS EX55-59 PBMC
TX8 DMD DEL 8-45 PBMC
TX9 DMD DEL 45-50 PBMC
TX10 DMD N/A PBMC
TX11 DMD DEL EX44 iPSC
TX12 DMD DEL EX44 iPSC
TX13 WT -- iPSC
TX14 DMD DUP EX4-8 PBMC
TX15 DMD DUP EX2 iPSC
TX16 DMD DEL EX52 iPSC
TX17 DMD DEL EX8-25 PBMC
HC01 WT N/A PBMC
HC02 WT N/A PBMC
TX18 DMD DEL EX45 PBMC
TX19 DMD DEL EX38 PBMC
TX20 DMD DUP EX17 PBMC
TX21 DMD DUP EX5-7 iPSC
TX22 DMD DUP EX53-57 iPSC
TX23 DMD DUP EX53-57 PBMC
CA01 Carrier DEL EX38 Carrier PBMC
HC01 ∆EX52 DMD DEL EX52 iPSC
HC01 ∆E43 DMD DEL EX43 iPSC
HC01 ∆EX51 DMD DEL EX51 iPSC
HC01 ∆EX8-9 DMD DEL EX8-9 iPSC

For additional information and cell line requests please Email Dr. Ning Liu.