Postdoctoral Position in Neuroimaging A postdoctoral training position is available in the BioMedical Imaging Research Lab (BiMIR) led by Dr. Jiaen Liu in the Advanced Imaging Research Center (AIRC) at UT Southwestern Medical Center to develop advanced high resolution MRI methods for neuroimaging applications. BiMIR has several exciting projects related to novel MRI acquisition and reconstruction, ultrahigh-field MRI (≥7 T), quantitative MRI (T2, T2* and MT) for myelin and iron

1 Napierala Lab protocol for culturing human iPSCs (May 2022) For details, please refer to “Maintenance of Human Pluripotent Stem Cells in mTeSR™1” Technical Manual (STEMCELL Technologies). Necessary Reagents Reagent Company Catalog Number BD MATRIGEL HESC-QUALIFIED Fisher Scientific 08-774-552 mTeSRTM1 Complete Kit STEMCELL Technologies 85850 Cryostor CS10 STEMCELL Technologies 07930 Dispase 1U/mL, 100mL STEMCELL Technologies 07923 Stemolecule Y27632 Stemgent 04-0012

1 Napierala Lab protocol for human skin fibroblast culture (May 2022) Necessary Reagents Reagent Company Catalog Number DMEM, high glucose Gibco/Life Technologies 11965-092 Fetal bovine serum Hyclone SH30910.03 MEM Non-essential amino acids (NEAA) Gibco/Life Technologies 11140-050 0.25% Trypsin-EDTA, phenol red Gibco/Life Technologies 25200-056 DPBS (1X) Gibco/Life Technologies 14190-144 Fibroblast Medium recipe: DMEM, high glucose 15% fetal bovine serum (FBS

1 Sendai virus reprogrammed iPSC Lines Line Clone# Sex GAA repeat number in fibroblasts GAA repeat number in iPSCs Earliest passage Karyotype data Karyotype passage 1 CTRL 3348 6 M Control size Control size P5 Yes, normal P11 2 CTRL 7522 5 F Control size Control size P9 Yes, normal P15 3 CTRL 6718 1 M Control size Control size P2 Yes, normal P4 4 CTRL 6718 6 M Control size Control size P2 Yes, normal P4 5 CTRL 6719 1 F Control size Control size

1 FRDA fibroblasts Short alleles <499 repeats Medium alleles 500 – 999 repeats Long alleles >1000 repeats B - indicates line established from a second, independent skin biopsy of the same individual Cell Line Sex Sampling Age Age of Onset GAA repeats Allele 1 Allele 2 4 M 30 11 597 848 21 M 35 8 622 738 50 M 33 13 353 616 66 M 70 41 110 590 68 F 21 7 570 1200 86 F 30 18 367 780 88 F 50 16 520 520 90 F 29 7 556 556 90B F 33 7 570 570 130 M 56 41

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. A Rohlmann, … , R E Hammer, J Herz J Clin Invest. 1998;101(3):689-695. https://doi.org/10.1172/JCI1240. The multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) has been postulated to participate in a number of diverse physiological and pathological processes ranging from the homeostasis of plasma lipoproteins, atherosclerosis, and

1Scientific RePoRTS | (2018) 8:4501 | DOI:10.1038/s41598-018-22819-3 www.nature.com/scientificreports Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation Antoine Abou-Jaoude1, Lise Badiqué1, Mohamed Mlih1, Sara Awan1, Sunning Guo1, Alexandre Lemle1, Clauda Abboud1, Sophie Foppolo1, Lionel Host1, Jérôme Terrand1, Hélène Justiniano1, Joachim Herz2, Rachel L. Matz1 & Philippe Boucher 1

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning Catherine R. Wasser1,2,*,>†, Irene Masiulis2,†, Murat S. Durakoglugil1,2, Courtney Lane- Donovan1,2, Xunde Xian1,2, Uwe Beffert2, Anandita Agarwala2, Robert E. Hammer3, and Joachim Herz1,2,4,5,* 1Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA 2Department of Molecular Genetics, University of Texas Southwestern Medical

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulation Yinyuan Ding1,2,3,*, Linzhang Huang4,*, Xunde Xian1,2,*, Ivan S. Yuhanna4, Catherine R. Wasser1,2, Michael Frotscher5, Chieko Mineo4, Philip W. Shaul4,†, and Joachim Herz1,2,6,7,8,† 1Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390, USA. 2Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas

Moral Reasoning in Scientific Research Cases for Teaching and Assessment Developed by Muriel J. Bebeau, University of Minnesota with Kenneth D. Pimple, Karen M. T. Muskavitch, Sandra L. Borden, and David H. Smith, Indiana University December 1995 These materials were developed for a project entitled “Teaching Research Ethics: A Workshop at Indiana University” (TRE). Funding was provided by the United States Department of Education’s Fund for the Improvement of Postsecondary Education