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Our laboratory studies mechanosensitive channels, primarily from microbes (although we are now extending our research to mammalian mechanosensors). 

Napierala Lab Publications

Read about Genomics and Bioinformatics

We focus on the lipid kinases that synthesize PIP2 (phosphatidylinositol phosphate 5 kinases, PIP5Ks) and PI4P (phosphatidylinositol 4 kinases, PI4Ks), as well as the regulatory proteins that respond to PIP2 and PI4P. 

Meet the Shay Lab team.

GABARAP recruits PI4KIIα to autophagosomes. Depletion of either GABARAP or PI4KIIα by siRNA, or overexpression of the dominant negative kinase-dead PI4KIIα, blocks autophagic flux by inhibiting autophagosome fusion with lysosomes to generate grossly enlarged autophagosomes.

Copyright © 2014 American Scientific Publishers All rights reserved Printed in the United States of America Article Journal of Biomedical Nanotechnology Vol. 10, 1–10, 2014 www.aspbs.com/jbn Phosphatidylserine-Targeted Molecular Imaging of Tumor Vasculature by Magnetic Resonance Imaging Heling Zhou PhD1, Jason H. Stafford PhD2, Rami Hallac PhD1, Liang Zhang PhD1, Gang Huang PhD3, Ralph P. Mason PhD1�3, Jinming Gao PhD2�3, Philip Thorpe PhD2, and Dawen Zhao MD,PhD1�∗ 1Departments of Radiology

We now want to know how gelsolin and gelsolin-like proteins behave in living cells. We are developing a fluorescence energy transfer reporter to monitor gelsolin activation in live cells.

Learn more about the Kraus Lab's research

Join us at the Chung Lab