Proc. Natd. Acad. Sci. USA Vol. 91, pp. 12027-12030, December 1994 Chemistry Determination of the effective charge of a protein in solution by capillary electrophoresis (protein charge ladders) JINMING GAO, FRANK A. GOMEZ, RALPH HARTER, AND GEORGE M. WHITESIDES Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, MA 02138 Contributed by George M. Whitesides, August 15, 1994 ABSTRACT This paper describes two methods to estimate the effective charge of a protein in

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Accounts of Chemical Research is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Affinity Capillary Electrophoresis Yen-Ho Chu, Luis Z. Avila, Jinming Gao, and George M. Whitesides Acc. Chem. Res., 1995, 28 (11), 461-468• DOI: 10.1021/ar00059a004 • Publication Date (Web): 01 May 2002 Downloaded from http://pubs.acs.org on May 14, 2009 More About This Article The permalink http

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Analytical Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Addition/Correction Using Capillary Electrophoresis To Follow the Acetylation of the Amino Groups of Insulin and To Estimate Their Basicities Jinming Gao, Milan Mrksich, Frank A. Gomez, and George M. Whitesides Anal. Chem., 1996, 68 (13), 2287-2287• DOI: 10.1021/ac9614001 • Publication Date (Web): 01 July 1996

Notes Synthesis of a Phosphonate Analog of Sialic Acid (Neu5Ac) Using Indium-Mediated Allylation of Unprotected Carbohydrates in Aqueous Media Jinming Gao, Valeri Martichonok, and George M. Whitesides* Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Received October 1, 1996 Introduction Sialic acid (Neu5Ac, 1), a constituent of sialoglycopro- teins1 and gangliosides,2 mediates a number of inter- cellular and cell-virion

Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase Qinyuan Wu,†,§ Jinming Gao,‡ Diane Joseph-McCarthy,‡ George B. Sigal,‡ James E. Bruce,† George M. Whitesides,*,‡ and Richard D. Smith*,† EnVironmental Molecular Sciences Laboratory Pacific Northwest National Laboratory Richland, Washington 99352 Department of Chemistry and Chemical Biology HarVard UniVersity, 12 Oxford Street Cambridge, Massachusetts 02138 ReceiVed August 28, 1996 Many biochemical processes are mediated

Protein Charge Ladders, Capillary Electrophoresis, and the Role of Electrostatics in Biomolecular Recognition JEFFREY D. CARBECK, IAN J. COLTON, JINMING GAO, AND GEORGE M. WHITESIDES* Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Received September 23, 1997 Introduction Life rests on a web of molecular recognition;1,2 the folding of proteins, the hybridization of nucleic acids, the recog- nition of signaling molecules by receptors, and the

Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods Brent D. Weinberg,1 Hua Ai,2 Elvin Blanco,3 James M. Anderson,4 Jinming Gao3 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China 3Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 4Institute of Pathology

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by �-lapachone Erik A. Bey†‡§, Melissa S. Bentle¶, Kathryn E. Reinicke�, Ying Dong†‡, Chin-Rang Yang‡, Luc Girard††, John D. Minna††, William G. Bornmann‡‡, Jinming Gao‡, and David A. Boothman†‡§ †Departments of Pharmacology and Oncology, Laboratory of Molecular Stress Responses, ‡Program in Cell Stress and Cancer Nanomedicine, Simmons Comprehensive Cancer Center, and ††Hamon Center for Therapeutic

Expert Review Functionalized Micellar Systems for Cancer Targeted Drug Delivery Damon Sutton,1 Norased Nasongkla,1,2 Elvin Blanco,1 and Jinming Gao1,3 Received November 6, 2006; accepted December 21, 2006; published online March 24, 2007 Abstract. Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10Y100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood