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Doxorubicin and b-Lapachone Release and Interaction with Micellar Core Materials: Experiment and Modeling DAMON SUTTON,*,� SHIHU WANG,� NORASED NASONGKLA,*,�,1 JINMING GAO,* AND ELENA E. DORMIDONTOVA�,2 *Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390; and �Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio 44106 Polymer micelles with two different core-forming blocks, poly(D,L

ARTICLES PUBLISHED ONLINE: 8 DECEMBER 2013 | DOI: 10.1038/NMAT3819 A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals Yiguang Wang1, Kejin Zhou1, Gang Huang1, Christopher Hensley2, Xiaonan Huang1, Xinpeng Ma1, Tian Zhao1, Baran D. Sumer3, Ralph J. DeBerardinis2 and Jinming Gao1* Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug

\ PEGSITACIANINE FOR THE SURGICAL DETECTION OF HEAD AND NECK CANCER PURPOSE INCLUSION DESIGN To investigate whether Pegsitacianine a fluorescent nanoparticle can image head and neck cancer and unknown primary head and neck cancer during surgery or biopsy. 1. Adults ≥ 18 years of age 2. Patients with stage 1-4 Head and Neck Squamous Cell Carcinoma (HNSCC) undergoing surgical excision 1. Phase 2 Clinical trial of Pegsitacianine, which is

Effect of fibrous capsule formation on doxorubicin distribution in radiofrequency ablated rat livers Elvin Blanco,1 Feng Qian,1 Brent Weinberg,1 Nicholas Stowe,2 James M. Anderson,3 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 3Institute of Pathology, University Hospitals of Cleveland, Cleveland, Ohio 44106 Received 24 October 2003

Development of B-Lapachone Prodrugs forTherapyAgainst Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase1Levels Kathryn E. Reinicke,1,2 Erik A. Bey,1,3 Melissa S. Bentle,1,4 JohnJ. Pink,1,3 Stephen T. Ingalls,4,6 Charles L. Hoppel,4,6,7 Rosana I. Misico,8 GiselaM. Arzac,8 Gerardo Burton,8William G. Bornmann,9 Damon Sutton,5 Jinming Gao,5 and David A. Boothman1,3,4 Abstract B-Lapachone, an o-naphthoquinone, induces a novel caspase- and p53-independent apoptotic

Noninvasive Monitoring of Local Drug Release Using X-ray Computed Tomography: Optimization and In Vitro/In Vivo Validation AGATA SZYMANSKI-EXNER,1 NICHOLAS T. STOWE,2 KYLE SALEM,1 ROEE LAZEBNIK,1 JOHN R. HAAGA,3 DAVID L. WILSON,1 JINMING GAO1,3 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 2Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 3Department of Radiology, University

1310 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 21, NO. 10, OCTOBER 2002 X-Ray Computed Tomography Methods forIn Vivo Evaluation of Local Drug Release Systems Kyle A. Salem, Student Member, IEEE, Agata Szymanski-Exner, Roee S. Lazebnik, Michael S. Breen, Jinming Gao, and David L. Wilson�, Member, IEEE Abstract—Recent advances in drug delivery techniques have necessitated the development of tools forin vivomonitoring of drug distributions. Gamma emission imaging and magnetic resonance imaging

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Journal of Controlled Release 91 (2003) 157–166 www.elsevier.com/ locate/ jconrel Q uantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers a ,1 b a a a ,*Feng Qian , Nicholas Stowe , Erin H. Liu , Gerald M. Saidel , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106,USA Received 31 October 2002