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Development and progression of cancer are frequently associated with altered rates of lipid synthesis, mobilization and metabolism in tumor cells. 

Postdoctoral Training in Gene Regulation Molecular Mechanisms, Genomics, Mouse Models, Translational/Clinical A postdoctoral training position is available in the laboratory of Dr. Cristel Camacho, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study gene regulation in breast cancer. The Camacho Lab has several exciting projects related to hormone signaling and gene regulation, focusing on transcription and nuclear endpoints

The application of Focused Ultrasound (FUS) coupled with IV administration of microbubbles is a unique method whereby localized opening of the BBB can be achieved in a non-invasive manner.

Information regarding User Group A, Discovery of PET Applications & Imaging Metabolic Alterations in Pediatric Oncology, for UT Southwestern's Cyclotron and Radiochemistry Program Pediatric Core.

2292 J . Med. Chem. 1996,38, 2292-2301 Increasing Binding Constants of Ligands to Carbonic Anhydrase by Using “Greasy Tails” Jinming Gao, Shuang Qiao, and George M. Whitesides* Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Received February 13, 1995@ Two series ofpara-substituted benzenesulfonamides have been examined as inhibitors for bovine carbonic anhydrase I1 (CAII, EC 4.2.1.1). Both series have hydrophobic alkyl group R connected

Chung Lab publications

Reactivity Umpolung-1 Ready Reactivity Umpolung: reversal of normal polarity electrophiles become nucleophiles nucleophiles become electrophiles Outline: 1. electrophilic heteroatoms 2. acyl anions 3. homoenolates 4. the cyclopropane trick 5. sulfone chemistry Normal reactivity: X x = heteroatom d = donor (Nu-) a = acceptor (E+) d a d a d X X X X or 1 3 1 5 How to make: X X or X X 1 2 1 4 complimentary

Metabolic reprogramming is now firmly established as a hallmark of cancer

Protecting Groups in Organic Synthesis-1 Ready Protecting groups are a sad fact of synthetic chemistry They are usually needed, but rarely desired Many syntheses have stalled because of trouble putting on or removing protecting groups 4 basic questions to address when choosing a P.G.: 1. Can I put it on where and only where I want? 2. Can I take it and only it off? 3. Will it survive all future reaction conditions? 4. Will it

Selected publications of Herz Lab