Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase Jinming Gao,* Qinyuan (Quincey) Wu,# Jeffrey Carbeck,* Q. Paula Lei,# Richard D. Smith,# and George M. Whitesides* *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and #Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352 USA ABSTRACT This paper describes the use of electrospray ionization

ARTICLE Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window Xu Wang 1, Jonathan Wilhelm 1, Wei Li1, Suxin Li1, Zhaohui Wang1, Gang Huang1, Jian Wang1, Houliang Tang1, Sina Khorsandi 2, Zhichen Sun 1, Bret Evers 3 & Jinming Gao 1✉ Stimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision of diagnostic or therapeutic outcomes. In this study, we report the

628 graft morphology and function have not been adequately addressed. A systematic understanding of the effects of in vitro parameters will be important if these culture tech- niques are to be translated to human cells for the develop- ment of autologous human vascular grafts that have acceptable long-term function in vivo.7 A large array of parameters has an impact on the devel- opment of engineered tissues, including cell sourcing, bioreactor design, nutrient medium composition, growth

Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles Published as part of the Accounts of Chemical Research special issue “Chemistry in Cancer Immunotheranostics”. Suxin Li, Zachary T. Bennett, Baran D. Sumer, and Jinming Gao* Cite This: Acc. Chem. Res. 2020, 53, 2546−2557 Read Online ACCESS Metrics & More Article Recommendations CONSPECTUS: Immunotherapy has transformed the field of oncology and patient care. By leveraging the

Journal of Controlled Release 83 (2002) 415–425 www.elsevier.com/ locate/ jconrel N oninvasive monitoring of local drug release in a rabbit radiofrequency (RF) ablation model using X-ray computed tomography a b a aAgata Szymanski-Exner , Nicholas T. Stowe , Roee S. Lazebnik , Kyle Salem , a c a,c ,*David L. Wilson , John R. Haaga , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve

Reductions General Resource: Trost, Comp. Org. Syn. 1991, vol 8 March,1992, chap 19 Carey and Sundberg, vol B, Chap 5 Smith, Organic Synthesis, Chap 4 Material organized (roughly) by transformation From March, 1992, p1208 H H Two general classes: Transition metal hydrogenation and dissolving metal reduction Hydrogenation: Covered in much more detail in Advanced Synthesis and Catalysis. H HM H2 General trends: more substituted = slower relationship of pressure:rate often not simple

In vivo drug distribution dynamics in thermoablated and normal rabbit livers from biodegradable polymers Jinming Gao,1 Feng Qian,1 Agata Szymanski-Exner,1 Nicholas Stowe,2 John Haaga3 1Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 3Department of Radiology, University Hospitals of Cleveland, Cleveland, Ohio

CANCER RESEARCH | MOLECULAR CELL BIOLOGY HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis Yanling Niu1, Lei Bao1, Yan Chen1, ChenliangWang1, Maowu Luo1, Bo Zhang1, Mi Zhou1, Jennifer E. Wang1, Yisheng V. Fang1, Ashwani Kumar2, Chao Xing2,3,4, Yingfei Wang1,5, and Weibo Luo1,6 ABSTRACT ◥ Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here

Articles Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry Jinming Gao,† Xueheng Cheng,‡ Ruidan Chen,‡ George B. Sigal,† James E. Bruce,‡ Brenda L. Schwartz,‡ Steven A. Hofstadler,‡ Gordon A. Anderson,‡ Richard D. Smith,*,‡ and George M. Whitesides*,† Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, and Environmental Molecular Sciences Laboratory, Pacific

Received May 10, 2020, accepted May 24, 2020. Date of publication xxxx 00, 0000, date of current version xxxx 00, 0000. Digital Object Identifier 10.1109/ACCESS.2020.2999079 Mining Domain Knowledge: Improved Framework Towards Automatically Standardizing Anatomical Structure Nomenclature in Radiotherapy QIMING YANG 1,2, HONGYANG CHAO 1,2, (Member, IEEE), DAN NGUYEN1, AND STEVE JIANG1 1Medical Artificial Intelligence and Automation Laboratory, Department of Radiation Oncology, University of