Search

6418 Chem. Commun., 2013, 49, 6418--6420 This journal is c The Royal Society of Chemistry 2013 Cite this: Chem. Commun.,2013, 49, 6418 A novel class of polymeric pH-responsive MRI CEST agents† Shanrong Zhang,ab Kejin Zhou,a Gang Huang,a Masaya Takahashi,b A. Dean Sherry*bc and Jinming Gao*ac In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

3896 Published OnlineFirst on May 11, 2010 as 10.1158/0008-5472.CAN-09-3995 Integrated Systems and Technologies Cancer Research β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy Elvin Blanco1, Erik A. Bey1,2, Chalermchai Khemtong1, Su-Geun Yang1, Jagadeesh Setti-Guthi1, Huabing Chen1, Chase W. Kessinger1, Kevin A. Carnevale3, William G. Bornmann4, David A. Boothman1,2, and Jinming Gao1 Abstract Authors' A Oncology, Texas So 3Departme of South C Experiment Center, Ho

Oxidations at Carbon General references March, Advanced Org Chem, 1992, 1158-1238 Trost, Comp. Org. Syn. 1991, vol 7 Carey and Sundberg, Advanced Org Chem, part B, 615-664 Smith, Org Syn, Chap 3 H CH3 C(-IV) R CH3 C(-III) R CH2 OH C(-1) R CH OH RR H2 C R C(-II) R C O R C(0) R CH O C(+I) H CH2 OH C(-II) H CH O C(0) C(II) R COR O C(+III) H COH O C(+II) O C O C(+IV) RO COR O C(+IV) alkane RCH2M RCH2SiR3 RCH2X X=halide RCH2NR2 RCH2SR RCH2PR2 Acetal: RCH(OR)2

Original Research In vivo angiogenesis imaging of solid tumors by avb3-targeted, dual-modality micellar nanoprobes Chase W Kessinger1, Chalermchai Khemtong1, Osamu Togao2, Masaya Takahashi2, Baran D Sumer3 and Jinming Gao1 1Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center; 2Advanced Imaging Research Center; 3Department of Otolaryngology, University of Texas Southwestern Medical Center at Dallas, ND2.210, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

Substrate pKa's. Numbers are approximations for outside the range -2 - 16, but useful to know. For an extensive list, see http://www.chem.wisc.edu/areas/reich/pkatable/ Inorganics H2O DMSO CF3SO3H -14 HCl -8 H3O+ -2 H2O 16 NH4Cl 9 Organic X-H AcOH 5 12 O+ CH3Ph H -6 Me2OH+ -4 CH3SO3H -3 2 NH+ 5 3 N H O H 15 26 MeOH 16 28 17 29 NH3 36 38 41 EWG-CH NO2-CH3 10 17 O O 9 13 O EtO O 11 14 O EtO OEt O 13 16 O 20 27 O t-BuO 25 30 O Me2N 35 O S 3533PhOH 10 18

U N C O R R E C TE D P R O O F Please cite this article in press as: Chen, H. et al., Nanonization strategies for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009 Drug Discovery Today � Volume 00, Number 00 �March 2010 REVIEWS Nanonization strategies for poorly water-soluble drugs Huabing Chen1, Chalermchai Khemtong1, Xiangliang Yang2, Xueling Chang3 and Jinming Gao1 1Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center

1 R Co(CO)3(OC)3Co O O Δ (OC)3Co O R H O R H2 R H O (OC)4Co R (OC)4Co Co(CO)4 H H (CO)4CoH H2 CO R O H R CO (OC)3Co R (OC)3Co H R H2 R (OC)3Co R The Oxo process -developed in 1938 by Otto Roelen -Principle method for hydroformylation of terminal alkenes industrially -more that 4 million tons aldehyde annually -linear aldehydes more desirable Co2(CO)8 H2/CO (200-300 atm) 120-170 oC linear (normal) branched (iso) + chemical feed stocks linear alcohols

Lithographically defined uniform worm-shaped polymeric nanoparticles This article has been downloaded from IOPscience. Please scroll down to see the full text article. 2010 Nanotechnology 21 095301 (http://iopscience.iop.org/0957-4484/21/9/095301) Download details: IP Address: 129.112.109.250 The article was downloaded on 14/10/2010 at 15:22 Please note that terms and conditions apply. View the table of contents for this issue, or go to the journal homepage for more Home Search

Ready; Catalysis Nonlinear Effects Outline Definitions Origins of nonlinear effects in enantioselective reactions ML2 model Reservoir model Transition-state model Kinetic aspects of nonlinear effects Asymmetric amplification Cool tricks Origin of biotic asymmetry? Key reviews Kagan, ACIEE, 1998, 2922 (a pretty complete review, source of many of my figures) Kagan, Advanced Syn. Cat., 2001, 227 (an overview) Blackmond, Accts, 2000, 402 (kinetic aspects) Soai