Search

Expert Review Functionalized Micellar Systems for Cancer Targeted Drug Delivery Damon Sutton,1 Norased Nasongkla,1,2 Elvin Blanco,1 and Jinming Gao1,3 Received November 6, 2006; accepted December 21, 2006; published online March 24, 2007 Abstract. Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10Y100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood

Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy BRENT D. WEINBERG,1 ELVIN BLANCO,2 JINMING GAO2 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 2Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390 Received 26 January 2007; accepted 17 April 2007 Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002

Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods Feng Qian, Agata Szymanski, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 18 August 2000; accepted 5 October 2000 Abstract: A compression–heat molding procedure was de- veloped to fabricate poly(D,L-lactide-co-glycolide) (PLGA) controlled release drug delivery devices

Correlation between the Charge of Proteins in Solution and in the Gas Phase Investigated by Protein Charge Ladders, Capillary Electrophoresis, and Electrospray Ionization Mass Spectrometry Jeffrey D. Carbeck,† Joanne C. Severs,‡ Jinming Gao,† Qinyuan Wu,‡ Richard D. Smith,* ,‡ and George M. Whitesides*,† Department of Chemistry and Chemical Biology, HarVard UniVersity, 12 Oxford Street, Cambridge, Massachusetts 02138, and EnVironmental Molecular Science Laboratory, Pacific Northwest National

Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase Jinming Gao,* Qinyuan (Quincey) Wu,# Jeffrey Carbeck,* Q. Paula Lei,# Richard D. Smith,# and George M. Whitesides* *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and #Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352 USA ABSTRACT This paper describes the use of electrospray ionization

10 to 70% methanol in 50 mM KH2PO4 over 25 min, 10 ml/min, monitor at 380 nm). Next, the HPLC- purified mixture was desalted on the same column (methanol was removed on a rotary evaporator, and the sample loaded in H2O and eluted with 90% methanol) and lyophilized, yielding the purified Nvoc-aa-S-CoA (40 to 80% yield) as a yellow solid. For preparation of the deprotected aa-S-CoAs, the solution of Nvoc-aa-S-CoA collected from the HPLC purification was directly photolysed (4°C, 350 nm, 1 hour

In vivo drug distribution dynamics in thermoablated and normal rabbit livers from biodegradable polymers Jinming Gao,1 Feng Qian,1 Agata Szymanski-Exner,1 Nicholas Stowe,2 John Haaga3 1Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 3Department of Radiology, University Hospitals of Cleveland, Cleveland, Ohio

Forms and templates researchers may need to obtain approval from the Human Research Protection Program (HRPP).

Journal of Controlled Release 83 (2002) 415–425 www.elsevier.com/ locate/ jconrel N oninvasive monitoring of local drug release in a rabbit radiofrequency (RF) ablation model using X-ray computed tomography a b a aAgata Szymanski-Exner , Nicholas T. Stowe , Roee S. Lazebnik , Kyle Salem , a c a,c ,*David L. Wilson , John R. Haaga , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve

Policies and guidance help ensure compliance with University, state, and federal regulations through education and collaboration with the research community.