The Structural Biology Lab (SBL) provides access and assistance with the techniques of X-ray crystallography, small angle X-ray scattering and high-resolution imaging as well as single particle reconstruction in cryo-electron microscopy.

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.

CRSM Trainee Fellowships support given to talented graduate students and postdoctoral trainees whose research focuses on tissue formation in health and disease, tissue repair, or tissue regeneration.

The DNA Microarray Core provides centralized access to microarray and related technology for the UT Southwestern research community

Bioanalysis and Pharmacokinetics Bioanalysis : The Preclinical Pharmacology Core makes use of three combination triple quadrupole/ion trap mass spectrometers from AB Sciex: a 3200 QTRAP® System, a 4000 QTRAP® System, and a QTRAP ® 6500+ System. All three mass spectrometers are coupled to Shimadzu Prominence liquid chromatography instruments with 80 to 100-place autosamplers. Development of an analytical method requires several steps: optimization of an MS/MS method to detect the compound with

In Vitro Metabolic Stability Unless a compound is a pro-drug, good metabolic stability is important for achieving therapeutic concentrations for the sufficient amount of time in vivo. The liver is the most important site of drug metabolism in vivo , although other organs (gastrointestinal tract and lung, among others) may play a role. The Core can assess metabolic stability in a variety of different systems, including microsomes, hepatocytes, S9 fractions, and plasma. Microsomes are typically

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

Metabolite Profiling If a particular chemical series shows poor metabolic stability, knowledge of the specific metabolites formed can aid chemists in the design of more stable analogues. A comparison of the metabolites formed in different species can also aid in the selection of appropriate species for toxicology studies. The Core has a limited ability to evaluate commonly generated metabolites and to predict the general location of those change based on MS/MS analysis using one of its three

Aqueous Solubility Determination Poor aqueous solubility can limit the ability to develop lead compounds as in vivo probes and therapeutics. Aqueous solubility affects absorption, formulation and ability of a compound to be delivered in sufficient concentrations to be active, and even in vitro activity. The Core offers two types of assays: Thermodynamic (or Equilibrium) Solubility Measures solubility of a compound as a saturated solution in equilibrium. Solubility can be dependent on pH and the

The Center for Regenerative Science and Medicine aims to promote interactions between scientists and clinicians and build an integrated scientific environment.