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Key Research Cores To support research efforts, four cores provide state-of-the-art services that augment the capabilities, availability, and budgets of individual NORC investigators: Animal Phenotyping/Metabolism Core Provides an array of blood metabolites and hormones, 50-plus metabolic cages, telemetry measurements of blood pressure, heart rate, core body temperature, and activity, multiple imaging modalities to characterize fat distribution, and hyperinsulinemic-euglycemic clamps and primary

The Human Research Protection Program's Sponsor Investigator Support provides assistance to physicians who wish to treat patients with investigational drugs or devices outside of a clinical investigation.

Get to know the real people behind this two-year program designed for junior faculty becoming successful, independently funded clinical and translational science investigators.

CMRU Core Offerings: Wet Lab Our state-of-the-art wet lab is equipped with specialized analytical tools and technologies, such as the Cobas e411 and Cobas c311 modules. These capabilities allow us to perform a wide array of diagnostic tests, from biochemical panels to drug screening, ensuring precise and timely results for your research needs. CMRU lab employs Roche's Cobas e411 and Cobas c311 analyzers to boost laboratory efficiency and diagnostic precision. The Cobas e411 is an automated

Co-IP Experiments Introduction One of the most common types of experiment submitted for analysis in the Proteomics Core is the Co-IP experiment. An antibody against endogenous or tagged protein is used to pull down a protein of interest. The goal of the experiment is to see what comes down with that protein, and is a potential interactor. Often Co-IPs will be compared across different treatments or conditions. Performing a Co-IP experiment with the core We offer a qualitative or quantitative

Computing and Data Analysis Continuous improvement in mass-spectrometry instrumentation means that proteomics facilities are generating a growing amount of data, and tackling increasingly complex datasets. The rise of quantitative proteomics in particular demands robust data analysis techniques to ensure high quality results are generated for users. The UTSW Proteomics Core is embracing the need for high quality proteomics data analysis by using the best free and commerical software, and

PTM Identification Introduction The presence or absence of post-translational modifications (PTMs), such as phosphorylation, on a protein are often as interesting as the presence of absence of the protein itself. The PTM ID service offers identification of PTMs on a protein from a purified protein or from a sample enriched for a specific PTM of interest. A common way to submit purified proteins is by running your sample into an SDS-PAGE gel, to isolate the protein of interest from contaminants

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.

The McDermott Center Human Genetics Clinical Lab is dedicated to help accelerate the pace of human genetic research by providing skilled assistance with collecting and storing biologic specimens.

The Provost’s Initiative for Diverse Emerging Scholars (PROVIDES) Program increases diversity within the postdoctoral community.