UT Southwestern researchers have discovered a mechanism that cells use to degrade microRNAs (miRNAs), genetic molecules that regulate the amounts of proteins in cells.

People with Type 2 diabetes had significantly fewer heart attacks, strokes, heart failures, and deaths from cardiovascular disease when their blood pressure was lower than the current standard goal, a UT Southwestern Medical Center researcher and his colleagues found.

A team led by UT Southwestern scientists has discovered a mechanism that promotes metastasis in pancreatic, breast, and potentially other cancers along with a new druggable therapeutic target based on this mechanism to block metastases.

Ancient viral remnants in the human genome are activated during pregnancy and after significant bleeding in order to increase blood cell production, an important step toward defining the purpose of “junk DNA” in humans, according to new research from Children’s Medical Center Research Institute at

Contrary to how tumors operate while still in the kidney, metastatic kidney cancers rely heavily on mitochondrial metabolism, according to new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Nature.

Over the first year of the COVID-19 pandemic, almost 30% of patients with obesity gained more than 5% of their body weight, and 1 in 7 gained more than 10%. While diet and exercise habits were factors, people with the highest levels of stress, anxiety, and depression reported the most weight gain.

Combining a common chemotherapy drug with an experimental nanotechnology allowed the drug to cross the blood-brain barrier and increased the survival rate in a mouse model of glioblastoma up to 50%, a team led by researchers from UT Southwestern Medical Center and UT Dallas found.

A gene previously linked to autism spectrum disorder (ASD) by UT Southwestern Medical Center researchers appears to play an important role in steering cells in the brain’s hippocampus toward their ultimate identities, the same team reported in a new study. The findings, published in Science Advances

A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types.

A gene called Npas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brain’s circadian clock, new research led by UT Southwestern scientists suggests.