Epoxidation, Dihydroxylation, and the Utility of Epoxides and Diols Ready Outline: Epoxidation Condensation approaches Darzens condensation Sulfur ylides With organic peroxides Peroxy acids Peroxy iminic acids Dioxiranes DMDO Enantioselective versions Metal-catalyzed Approaches V(O)(acac)2 Sharpless AE Metal Oxo’s MTO Fe, Pt and Mn-based (Salen)Mn Jacobsen AE Epoxide Ring Opening Opening under acid or basic conditions Organocopper additions Reactions of epoxy alcohols Dihydroxylation

JOURNAL OF RAMAN SPECTROSCOPY, VOL. 27, 549-554 (1996) Structure Characterization of W03/Zr02 Catalysts by Raman Spectroscopy Biying Zhao,* Xianping Xu, Jinming Gao, Qiang Fu and Youqi Tang Institute of Physical Chemistry, Peking University, Beijing 100871, China WO,/ZrO, catalysts prepared by different methods are distinct in their catalytic behaviour. In this work, WO,/ZrO, catalysts prepared by impregnating Zr(OH), and crystallized ZrO, and then calcining at selected temperatures

Reagent/Reaction Use Ref Note DMSO/DCC (Pfitzner- Moffatt or Moffatt) Alcohol ketone/aldehyde Jacs 1963, 3027; Mech: JACS, 1965, 5561, JOC, 1967, 1926 First DMSO-based; DCC pain to remove; EDCI better DMSO/Ac2O “ Jacs 1967, 2416 DMSO/TFAA “ Jacs, 1975, 2758 DMSO/SO3-Pyridine (Parikh- Doering) “ JACS, 1967, 5505 Often under ambient conditions; best for α-chiral aldehydes/ketones (COCl)2/DMSO (swern) “ JOC, 1978, 2480; mech: Tet. 1978, 1651 Most commonly used; DMSO/Ac2O

Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase Qinyuan Wu,†,§ Jinming Gao,‡ Diane Joseph-McCarthy,‡ George B. Sigal,‡ James E. Bruce,† George M. Whitesides,*,‡ and Richard D. Smith*,† EnVironmental Molecular Sciences Laboratory Pacific Northwest National Laboratory Richland, Washington 99352 Department of Chemistry and Chemical Biology HarVard UniVersity, 12 Oxford Street Cambridge, Massachusetts 02138 ReceiVed August 28, 1996 Many biochemical processes are mediated

Oxidations at Carbon General references March, Advanced Org Chem, 1992, 1158-1238 Trost, Comp. Org. Syn. 1991, vol 7 Carey and Sundberg, Advanced Org Chem, part B, 615-664 Smith, Org Syn, Chap 3 H CH3 C(-IV) R CH3 C(-III) R CH2 OH C(-1) R CH OH RR H2 C R C(-II) R C O R C(0) R CH O C(+I) H CH2 OH C(-II) H CH O C(0) C(II) R COR O C(+III) H COH O C(+II) O C O C(+IV) RO COR O C(+IV) alkane RCH2M RCH2SiR3 RCH2X X=halide RCH2NR2 RCH2SR RCH2PR2 Acetal: RCH(OR)2

ARTICLES PUBLISHED ONLINE: 8 DECEMBER 2013 | DOI: 10.1038/NMAT3819 A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals Yiguang Wang1, Kejin Zhou1, Gang Huang1, Christopher Hensley2, Xiaonan Huang1, Xinpeng Ma1, Tian Zhao1, Baran D. Sumer3, Ralph J. DeBerardinis2 and Jinming Gao1* Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug

Protecting Groups in Organic Synthesis-1 Ready Protecting groups are a sad fact of synthetic chemistry They are usually needed, but rarely desired Many syntheses have stalled because of trouble putting on or removing protecting groups 4 basic questions to address when choosing a P.G.: 1. Can I put it on where and only where I want? 2. Can I take it and only it off? 3. Will it survive all future reaction conditions? 4. Will it

Proc. Natd. Acad. Sci. USA Vol. 91, pp. 12027-12030, December 1994 Chemistry Determination of the effective charge of a protein in solution by capillary electrophoresis (protein charge ladders) JINMING GAO, FRANK A. GOMEZ, RALPH HARTER, AND GEORGE M. WHITESIDES Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, MA 02138 Contributed by George M. Whitesides, August 15, 1994 ABSTRACT This paper describes two methods to estimate the effective charge of a protein in

Reactivity Umpolung-1 Ready Reactivity Umpolung: reversal of normal polarity electrophiles become nucleophiles nucleophiles become electrophiles Outline: 1. electrophilic heteroatoms 2. acyl anions 3. homoenolates 4. the cyclopropane trick 5. sulfone chemistry Normal reactivity: X x = heteroatom d = donor (Nu-) a = acceptor (E+) d a d a d X X X X or 1 3 1 5 How to make: X X or X X 1 2 1 4 complimentary

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Accounts of Chemical Research is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Affinity Capillary Electrophoresis Yen-Ho Chu, Luis Z. Avila, Jinming Gao, and George M. Whitesides Acc. Chem. Res., 1995, 28 (11), 461-468• DOI: 10.1021/ar00059a004 • Publication Date (Web): 01 May 2002 Downloaded from http://pubs.acs.org on May 14, 2009 More About This Article The permalink http