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ll Review Theranostic gastrointestinal residence systems Binbin Ying,1,4 Hao Huang,2,3,4 Yuyan Su,2 Julia G. Howarth,1 Zhen Gu,2,* and Kewang Nan2,* 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 3College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China 4These authors contributed equally *Correspondence: guzhen@zju.edu.cn

Reactivity Umpolung-1 Ready Reactivity Umpolung: reversal of normal polarity electrophiles become nucleophiles nucleophiles become electrophiles Outline: 1. electrophilic heteroatoms 2. acyl anions 3. homoenolates 4. the cyclopropane trick 5. sulfone chemistry Normal reactivity: X x = heteroatom d = donor (Nu-) a = acceptor (E+) d a d a d X X X X or 1 3 1 5 How to make: X X or X X 1 2 1 4 complimentary

Article https://doi.org/10.1038/s41467-024-51102-5 An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut Kewang Nan 1,2,3,13 , Kiwan Wong3,13, Dengfeng Li 4,5,13, Binbin Ying2,3,13, James C. McRae2, Vivian R. Feig2,3, Shubing Wang3, Ningjie Du 6, Yuelong Liang7, Qijiang Mao7, Enjie Zhou7, Yonglin Chen3, Lei Sang8, Kuanming Yao 4, Jingkun Zhou 4,5, Jian Li 4,5, Joshua Jenkins 3, Keiko Ishida3, Johannes Kuosmanen2, Wiam Abdalla

Evaluation of dry textile electrodes for long‑term electrocardiographic monitoring Milad Alizadeh‑Meghrazi1,2,8*  , Binbin Ying3,8, Alessandra Schlums4,8, Emily Lam2,8, Ladan Eskandarian5,8, Farhana Abbas6,8, Gurjant Sidhu7,8, Amin Mahnam8, Bastien Moineau8 and Milos R. Popovic1,2  Background Biopotentials or electrophysiological signals are widely utilized in health monitoring and diagnostics. For example, through electrocardiography (ECG), cardiac activity is recorded and information

Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles Published as part of the Accounts of Chemical Research special issue “Chemistry in Cancer Immunotheranostics”. Suxin Li, Zachary T. Bennett, Baran D. Sumer, and Jinming Gao* Cite This: Acc. Chem. Res. 2020, 53, 2546−2557 Read Online ACCESS Metrics & More Article Recommendations CONSPECTUS: Immunotherapy has transformed the field of oncology and patient care. By leveraging the

1 updated May 2025 FRDA fibroblasts Short alleles < 499 repeats Medium alleles 500 – 999 repeats Long alleles >1000 repeats B - indicates line established from a second, independent skin biopsy of the same individual nd - not determined Cell Line Sex Sampling Age Age of Onset GAA repeats Allele 1 Allele 2 4 M 30 11 597 848 21 M 35 8 622 738 50 M 33 13 353 616 66 M 70 41 110 590 68 F 21 7 570 1200 86 F 30 18 367 780 88 F 50 16 520 520 90 F 29 7 556 556

Articles https://doi.org/10.1038/s41551-020-00675-9 1Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 2Department of Pathology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 3Department of Otolaryngology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 4Howard Hughes

Didactic Questions 1. Epimysium surrounds A. skeletal muscle fibers B. cardiomyocytes C. smooth muscle cells D. skeletal muscle fascicles E. skeletal muscles 2. Perimysium surrounds A. skeletal muscle fibers B. cardiomyocytes C. smooth muscle cells D. skeletal muscle fascicles E. skeletal muscles 3. Endomysium surrounds A. skeletal muscle fibers B. cardiomyocytes C. smooth muscle cells D. skeletal muscle fascicles E. skeletal muscles 4. Fascicles are A. groupings of

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions Xinpeng Ma,†,‡ Yiguang Wang,†,‡ Tian Zhao,† Yang Li,† Lee-Chun Su,† Zhaohui Wang,† Gang Huang,† Baran D. Sumer,§ and Jinming Gao*,†,∥ †Department of Pharmacology and §Department of Otolaryngology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States ∥Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, United

1 updated May 2025 Napierala Lab protocol for human skin fibroblast culture Necessary Reagents Reagent Company Catalog Number DMEM, high glucose Gibco/Life Technologies 11965-092 Fetal bovine serum Hyclone SH30910.03 MEM Non-essential amino acids (NEAA) Gibco/Life Technologies 11140-050 0.25% Trypsin-EDTA, phenol red Gibco/Life Technologies 25200-056 DPBS (1X) Gibco/Life Technologies 14190-144 Dimethyl sulfoxide (DMSO) Sigma D8418-100ML Fibroblast Medium recipe