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Get to know our Principal Investigator and team of researchers at Helen Yin Lab.

We now want to know how gelsolin and gelsolin-like proteins behave in living cells. We are developing a fluorescence energy transfer reporter to monitor gelsolin activation in live cells.

Bioorganic Chemistry cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery** Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, and Jinming Gao* Low water solubility, rapid phagocytic and renal clearance, and systemic toxicity represent three major barriers that limit the therapeutic use of many hydrophobic antitumor agents such as doxorubicin (DOXO) and paclitaxel.[1] Various drug- delivery systems, among which polymeric micelles have

Ther Pro Poly Ying D Jer-Ts Abst Intro Pro in me dence cance therap ation treatin ternal Gy ha stages rate (2 prosta Author Oncolo 5Urolog Southw Note: S Online Y. Don Corres Stress 6001 F Phone: UTSou doi: 10 ©2010 Cance8088 Published OnlineFirst on October 12, 2010 as 10.1158/0008-5472.CAN-10-1418 Cancer esearch apeutics, Targets, and Chemical Biology state Cancer Radiosensitization through R (ADP-Ribose) Polymerase-1 Hyperactivation ong1,2, Erik A. Bey1,2, Long-Shan Li1,2

J O U R N A L O F M A T E R I A L S S C I E N C E 3 9 (2 0 0 4 ) 1429 – 1432 Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly H. AI , J . GAO Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 E-mail: jinming@cwru.edu Nanomaterials have found many important applica- tions in biomedical, pharmaceutical, electronic, and molecular diagnostic fields. The recent introduction of electrostatic layer-by-layer (LbL) self-assembly

Effect of fibrous capsule formation on doxorubicin distribution in radiofrequency ablated rat livers Elvin Blanco,1 Feng Qian,1 Brent Weinberg,1 Nicholas Stowe,2 James M. Anderson,3 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 3Institute of Pathology, University Hospitals of Cleveland, Cleveland, Ohio 44106 Received 24 October 2003

Napierala Lab Publications

Original Investigations Quantitative Computed Tomography Analysis of Local Chemotherapy in Liver Tissue After Radiofrequency Ablation1 Agata A. Exner, PhD, Brent D. Weinberg, BS, Nicholas T. Stowe, PhD, Anthony Gallacher, MS, David L. Wilson, PhD, John R. Haaga, MD, Jinming Gao, PhD Rationale and Objectives. Computed tomography (CT) was used to noninvasively monitor local drug pharmacokinetics from polymer implants in rat livers before and following radiofrequency ablation. Materials and

©2 005 LA ND ES BIO SCI EN CE. DO NO T D IST RIB UT E. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; ©2005 Landes Bioscience Matthew Ough4 Anne Lewis4 Erik A. Bey6 Jinming Gao6 Justine M. Ritchie3 William Bornmann7 David A. Boothman6 Larry W. Oberley2,3,4 Joseph J. Cullen1,2,3,4,5,* Departments of 1Surgery, 2Radiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa

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