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2010 | Mater. Horiz., 2024, 11, 2010–2020 This journal is © The Royal Society of Chemistry 2024 Cite this: Mater. Horiz., 2024, 11, 2010 Kirigami-enabled stretchable laser-induced graphene heaters for wearable thermotherapy† Junyu Chen,‡ab Yichao Shi,§a Binbin Ying, ¶ac Yajie Hu,b Yan Gao,b Sida Luo *b and Xinyu Liu *ad Flexible and stretchable heaters are increasingly recognized for their great potential in wearable thermotherapy to treat muscle spasms, joint injuries and arthritis

Article Luminal electrophysiologi cal neuroprofiling system for gastrointestinal neuromuscular diseases Graphical abstract Highlights d The LENS is a luminal electrophysiological neuroprofiling system d The LENS electrophysiologically characterizes the GI tract for disease diagnosis d Analytical metrics are generated to differentiate neuromuscular diseases d High-resolution spatial profiles identify ganglionic- aganglionic transition zones Authors Shriya S. Srinivasan, Sabrina Liu, Ryo

0123456789();: The traditional paradigm for medical diagnostics, which is still actively practised around the globe, relies on physi­ cians’ use of their five basic senses to make inferences about a patient’s health1. For example, palpation through orifices such as the oral cavity, rectum or vaginal canal is still the predominant diagnostic mechanism within the digestive and female reproductive tracts2. Although inexpensive and straightforward, such subjective meth­ ods are prone to

ll Review Macroencapsulated bacteria for in vivo sensing and therapeutics Yidan Lyu,1,10 Hao Huang,2,10 Yuyan Su,1,10 Binbin Ying,3,4 Wen-Che Liu,1 Kairu Dong,5 Ningjie Du,2 Robert S. Langer,6,7,* Zhen Gu,1,8,9,* and Kewang Nan1,8,9,* PROGRESS AND POTENTIAL Engineered bacterial therapeutics, with promising preclinical outcomes, are advancing in commercialization endeavors. However, their translation into widely accepted clinical products still poses significant challenges, demanding

IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING 1 A Sensory Soft Robotic Gripper Capable of Learning-Based Object Recognition and Force-Controlled Grasping Zhanfeng Zhou , Runze Zuo, Binbin Ying, Junhui Zhu , Yong Wang, Xin Wang, Member, IEEE, and Xinyu Liu , Member, IEEE Abstract— Soft robotic grippers possess high structural compliance and adaptability, allowing them to grasp objects with unknown and irregular shapes and sizes. To enable more dexterous manipulation, soft sensors

ll Review Theranostic gastrointestinal residence systems Binbin Ying,1,4 Hao Huang,2,3,4 Yuyan Su,2 Julia G. Howarth,1 Zhen Gu,2,* and Kewang Nan2,* 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 3College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China 4These authors contributed equally *Correspondence: guzhen@zju.edu.cn

Ying et al., Sci. Transl. Med. 17, eadq1975 (2025) 26 February 2025 S c i e n c e T r a n s l at i o n a l M e d i c i n e | R e s e a r c h A r t i c l e 1 of 11 M E D I C A L D E V I C E S An electroadhesive hydrogel interface prolongs porcine gastrointestinal mucosal theranostics Binbin Ying1,2,3, Kewang Nan1,2,4, Qing Zhu5, Tom Khuu2, Hana Ro1, Sophia Qin3, Shubing Wang2, Karen Jiang1, Yonglin Chen2, Guangyu Bao6, Josh Jenkins1,3, Andrew Pettinari1,3, Johannes Kuosmanen1,3

Article https://doi.org/10.1038/s41467-024-51102-5 An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut Kewang Nan 1,2,3,13 , Kiwan Wong3,13, Dengfeng Li 4,5,13, Binbin Ying2,3,13, James C. McRae2, Vivian R. Feig2,3, Shubing Wang3, Ningjie Du 6, Yuelong Liang7, Qijiang Mao7, Enjie Zhou7, Yonglin Chen3, Lei Sang8, Kuanming Yao 4, Jingkun Zhou 4,5, Jian Li 4,5, Joshua Jenkins 3, Keiko Ishida3, Johannes Kuosmanen2, Wiam Abdalla

Review Ingestible electronic capsules for in situ sensing of diverse biomarkers Chong Zhang,1,2,9 Hao Song,1,9 Junjie Zeng,1 Jian Chen,3 Chujun Ni,4 Ha Uk Chung,5 Kaichen Xu,6,* Binbin Ying,7,8,* and Kewang Nan1,2,3,* 1State Key Laboratory of Advanced Drug Delivery and Release Systems, School of Pharmacy, Zhejiang University, Hangzhou 310058, China 2Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 3Department of

\ PEGSITACIANINE FOR THE SURGICAL DETECTION OF HEAD AND NECK CANCER PURPOSE INCLUSION DESIGN To investigate whether Pegsitacianine a fluorescent nanoparticle can image head and neck cancer and unknown primary head and neck cancer during surgery or biopsy. 1. Adults ≥ 18 years of age 2. Patients with stage 1-4 Head and Neck Squamous Cell Carcinoma (HNSCC) undergoing surgical excision 1. Phase 2 Clinical trial of Pegsitacianine, which is