Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation Elvin Blanco,1* Brent D. Weinberg,1 Nicholas T. Stowe,2 James M. Anderson,3 Jinming Gao1* 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 3Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

Journal of Controlled Release 83 (2002) 427–435 www.elsevier.com/ locate/ jconrel C ombined modeling and experimental approach for the development of dual-release polymer millirods *Feng Qian, Gerald M. Saidel, Damon M. Sutton, Agata Exner, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106,USA Received 3 July 2002; accepted 7 August 2002 Abstract This paper describes a

Noninvasive Monitoring of Local Drug Release Using X-ray Computed Tomography: Optimization and In Vitro/In Vivo Validation AGATA SZYMANSKI-EXNER,1 NICHOLAS T. STOWE,2 KYLE SALEM,1 ROEE LAZEBNIK,1 JOHN R. HAAGA,3 DAVID L. WILSON,1 JINMING GAO1,3 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 2Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 3Department of Radiology, University

Journal of Controlled Release 91 (2003) 157–166 www.elsevier.com/ locate/ jconrel Q uantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers a ,1 b a a a ,*Feng Qian , Nicholas Stowe , Erin H. Liu , Gerald M. Saidel , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106,USA Received 31 October 2002

Effect of fibrous capsule formation on doxorubicin distribution in radiofrequency ablated rat livers Elvin Blanco,1 Feng Qian,1 Brent Weinberg,1 Nicholas Stowe,2 James M. Anderson,3 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 3Institute of Pathology, University Hospitals of Cleveland, Cleveland, Ohio 44106 Received 24 October 2003

Enhancement of Solubility and Bioavailability of �-Lapachone Using Cyclodextrin Inclusion Complexes Norased Nasongkla,1,2 Andy F. Wiedmann,2 Andrew Bruening,3 Meghan Beman,3 Dale Ray,4 William G. Bornmann,5 David A. Boothman,3 and Jinming Gao2,6 Received June 11, 2003; Accepted June 19, 2003 Purpose. To explore the use of cyclodextrins (CD) to form inclusion complexes with �-lapachone (�-lap) to overcome solubility and bio- availability problems previously noted with this drug. Methods

Bioorganic Chemistry cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery** Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, and Jinming Gao* Low water solubility, rapid phagocytic and renal clearance, and systemic toxicity represent three major barriers that limit the therapeutic use of many hydrophobic antitumor agents such as doxorubicin (DOXO) and paclitaxel.[1] Various drug- delivery systems, among which polymeric micelles have

Local carboplatin delivery and tissue distribution in livers after radiofrequency ablation A. Szymanski-Exner,1 A. Gallacher,2 N. T. Stowe,3 B. Weinberg,1 J. R. Haaga,4 J. Gao1,4 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 2Department of Analytical Chemistry, Ricerca, LLC, Concord, Ohio 3Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 4Department of Radiology, University Hospitals of

Interactions between self-assembled polyelectrolyte shells and tumor cells Hua Ai,1 John J. Pink,2 Xintao Shuai,1 David A. Boothman,2 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 2Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106 Received 23 August 2004; revised 22 November 2004; accepted 23 November 2004 Published online 1 April 2005 in

1 Joseph Martin Ready Department of Biochemistry University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-9038 (214) 648-0313 joseph.ready@utsouthwestern.edu Employment 2012 – Professor, UT Southwestern 2009 – Director, Medicinal Chemistry Laboratory, UT Southwestern 2007 – 2012 Associate Professor, UT Southwestern 2007 – Chair, chemistry training track, UT Southwestern 2003 – 2007 Assistant Professor, UT Southwestern and