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A genetic marker discovered by UT Southwestern Medical Center researchers could help physicians predict which patients with hepatocellular carcinoma are most likely to develop resistance to the drug lenvatinib. The finding, published in the journal Gastroenterology, may lead to alternative treatments for the most common form of liver cancer.

UT Southwestern Medical Center has been recognized for its decades of commitment to developing female leaders in medicine and science and its far-reaching impact in supporting and advancing women’s careers.

A drug in clinical trials as a treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) works with a one-two punch that shuts down triglyceride production and fatty acid synthesis in liver cells, UT Southwestern Medical Center researchers show in a new study.

In localized non-small cell lung cancer (NSCLC), a tumor’s ability to use carbon from glucose to feed the tricarboxylic acid (TCA) cycle predicts cancer spread beyond the lung, months to years before metastases are clinically apparent. According to this new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Cancer Discovery, tumors with this metabolic activity result in early patient death.

Scientists with UT Southwestern’s Peter O’Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication.

With knee replacement surgery becoming more common, Varatharaj Mounasamy, M.D., Professor of Orthopaedic Surgery at UT Southwestern Medical Center who specializes in hip and knee replacements, recommends taking off from work for a few weeks, joining a class to learn more about joint replacement, and attending physical therapy before surgery.

Researchers and data scientists at UT Southwestern Medical Center and MD Anderson Cancer Center have developed an artificial intelligence technique that can identify which cell surface peptides produced by cancer cells called neoantigens are recognized by the immune system.

To meet the growing demands for cancer treatment in Tarrant County and surrounding areas, UT Southwestern Medical Center is expanding its cancer services in the Fort Worth Medical District with construction of a new two-story Radiation Oncology campus that will house the city’s first MRI-guided precision radiation treatment.

The Division of Pediatric Surgery’s goal is to provide the fellow with advanced knowledge and training in managing and treating surgical disease in children.

UT Southwestern’s Clinical Research Foundations Training ensures a consistent understanding of the requirements to successfully deliver clinical research.