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An autoimmune side effect of immune checkpoint inhibitor (ICI) drugs could signal improved control of kidney cancer, according to a new study by researchers in UT Southwestern’s Kidney Cancer Program (KCP).

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or “jumping genes,” from hopping around the human genome.

Less than three weeks after getting on an organ transplant list for HIV-positive patients, John Welch got the call. A liver was available from a deceased donor, and it was an excellent match.

As you drift into unconsciousness before a surgery, general anesthetic drugs flowing through your blood are putting you to sleep by binding mainly to a protein in the brain called the ɣ-aminobutyric acid type A (GABAA) receptor.

New findings by UT Southwestern researchers help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals that cause the disease.

Dopamine, a chemical that sends messages between different parts of the brain and body, plays a key role in a variety of diseases and behaviors by interacting with receptors on cells.

Studies highlight how collaborative research can improve the diagnosis and treatment of childhood blood disorders such as aplastic anemia and MDS

The molecular changes that lead to Fuchs’ endothelial corneal dystrophy (FECD) occur decades before the disease causes blurry vision and other noticeable symptoms in patients.

A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals worldwide each year and kills hundreds of thousands.

Samuel Achilefu, Ph.D., the incoming Inaugural Chair of UT Southwestern Medical Center’s new Department of Biomedical Engineering, is among 100 members elected to the National Academy of Medicine (NAM) this year.