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The CLOCK gene, which serves as a master controller of circadian rhythms, may play a key role in the extraordinary cognitive abilities of humans as well as neuropsychiatric disorders that afflict them, UT Southwestern Medical Center researchers report.

Female sex hormones can significantly enhance the progression of the rare neurodegenerative eye disease retinitis pigmentosa (RP), according to a preclinical study by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, may lead to therapeutics to slow progression of the disease and help clinicians assess the risk of hormone therapies for female patients with genetic markers for the disease.

A team led by UT Southwestern Medical Center scientists has identified a specific stage of neurodevelopment when differentiating neural cells produce fewer ribosomes, which are responsible for making proteins.

Adding targeted radiation to chemotherapy prior to surgery may offer better control of pancreatic tumors – potentially reducing the rate of recurrence after treatment, according to a new study from UT Southwestern Medical Center. Published in Clinical Cancer Research, the novel study offers evidence of a more effective approach with biological insights for treating one of the most aggressive and lethal forms of cancer.

Former college athletes with a history of concussions were more likely to perceive themselves as cognitively impaired later in life if they had mood disorders such as depression and anxiety – even when testing showed no such decline in mental acuity, a study from UT Southwestern Medical Center researchers has found.

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling in cells, a process critical to human health. Their findings, published in Nature Communications, answer a fundamental question in cell biology and could lead to therapies for conditions including neurological disorders and cancer.

A far shorter, simpler, and less toxic treatment protocol for patients with triple-negative breast cancer produced outcomes similar to the current standard of care, a clinical trial co-led by a UT Southwestern Medical Center researcher shows.

UT Southwestern Medical Center and InterAct Therapeutics have announced an exclusive licensing agreement to develop and commercialize a groundbreaking computational platform and gene therapy pipeline targeting cancer metastasis.

Researchers at UT Southwestern Medical Center have discovered sex-specific differences in how fat accumulates in muscle and bone, uncovering patterns that could inform new approaches to treating age-related diseases.

An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer (NK) cells in an animal model, a study led by UT Southwestern Medical Center researchers shows.