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High-density lipoprotein (HDL), or “good” cholesterol, may play a vital role in conserving healthy brain matter in middle-aged adults, UT Southwestern Medical Center researchers report.

Mutations in a gene called OTP cause obesity by controlling the output of another gene already targeted by an anti-obesity drug, a study led by UT Southwestern Medical Center researchers shows.

UT Southwestern Medical Center is part of a major undertaking that will bring together more than 40 scientists, doctors, and industry experts handpicked from around the country to make vision-restoring whole eye transplants a reality.

Former college athletes with a history of concussions were more likely to perceive themselves as cognitively impaired later in life if they had mood disorders such as depression and anxiety – even when testing showed no such decline in mental acuity, a study from UT Southwestern Medical Center researchers has found.

David Mangelsdorf, Ph.D., Chair and Professor of Pharmacology and Professor of Biochemistry at UT Southwestern Medical Center, has been awarded the Hill Prize in Biological Sciences from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) in recognition of his long-standing research on orphan nuclear receptors – proteins in the cell nucleus that flip genes on and off and are triggered by unknown molecules.

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of interferon genes (STING) migrates from one cellular organelle to another, a necessary step in its activation.

UT Southwestern Medical Center is among 10 U.S. health systems selected for an initiative that aims to create and implement early detection programs for Alzheimer’s disease and other cognitive impairments.

Using a powerful microscopy technique, a team led by researchers at UT Southwestern Medical Center has gained insights into how the body uses vitamin K, an essential nutrient that plays a pivotal role in blood clotting and other physiological functions.

Mold growth in homes is a significant trigger for hypersensitivity pneumonitis (HP), an inflammatory lung disease, according to a new study led by UT Southwestern Medical Center. Published in PLOS One, the research represents the largest study to date linking home mold exposure to HP and the first from North Texas.

The Anne Burnett Marion School of Medicine at Texas Christian University and UT Southwestern Medical Center have joined forces to address some of the highest maternal morbidity rates in the country by forming the North Texas Maternal Health Accelerator (MHA).