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Congress did not pass a funding bill by September 30, 2025, so parts of the U.S. government has shut down. Past shutdowns show that some services continue, while others stop until funding is restored. Here is a summation of the status of certain impacted government agencies for your quick reference.

ChIP-Seq Libraries from 5–10 ng ChIP DNA are prepared using KAPA HTP Library Preparation Kit. The ChIP DNA is quantified on the Qubit® 2.0 Fluorometer from Invitrogen Samples are end repaired, 3' ends adenylated and barcoded with mµltiplex adapters. PCR amplified libraries are purified with Ampure XP…

Client Microscopy Facilities The Histo Pathology Core has microscopy facilities for clients to review and document completed histology slides, as well as to document wet tissues and cell culture preps that augment their histopathology. Self-Service Microscopy by Reservation These instruments, located…

Anatomic Pathology The Histo Pathology Core offers anatomic pathology services on an as needed basis to train clients as well as facilitate morphologic and histologic endpoints in large terminal studies with mice. The Core provides expert training in the following procedures with mice: Transcardial W…

Whole Genome Samples are run with the Genomic Tape on the Agilent Tapestation 4200 and their concentrations quantified by fluorometery. One microgram genomic DNA is sonicated using Covaris E220 ultrasonicator targeting 400bp. Libraries are prepared with the KAPA Hyper Prep Kit. Samples are end repair…

Exome Capture Current Protocol Twist Past Protocols SureSelect XT v4 Sample Preparation Guide Instructions for Performing the Nextera Rapid Capture Protocol TruSeq Sample Enrichment Guide Ready to submit samples? Order Online Pricing View Pricing Details Related Core Facilities Discover more informat…

Small RNA-Seq Current Protocol NEBNext Small RNA Past Protocol TruSeq Small RNA Sample Preparation Kit Ready to submit samples? Order Online Pricing View Pricing Details Related Core Facilities Discover more information on data analysis services by visiting the Bioinformatics Lab website . Back-to to…

Aqueous Solubility Determination Poor aqueous solubility can limit the ability to develop lead compounds as in vivo probes and therapeutics. Aqueous solubility affects absorption, formulation and ability of a compound to be delivered in sufficient concentrations to be active, and even in vitro activi…

mRNA-Seq Samples are run on the Agilent Tapestation 4200 to determine level of degradation thus ensuring only high quality RNA is used (RIN Score 8 or higher). The Qubit fluorimeter is used to determine the concentration prior to staring library prep. One microgram of total DNAse treated RNA is then …

The Metabolic Diagnostics and Mass Spectrometry laboratory performs testing using various mass spectrometry and chromatographic methods.