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Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, according to a study in preclinical models led by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, could have implications for patients with certain cancers that have KRAS-G12C mutations after resistance to drug therapy develops.

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of interferon genes (STING) migrates from one cellular organelle to another, a necessary step in its activation.

Using a cutting-edge imaging technology known as cryo-electron microscopy, researchers at UT Southwestern Medical Center have determined the structure of a protein called midnolin that’s crucial to the survival of malignant cells in some leukemias, lymphomas, and multiple myelomas.

Dallas ISD and the UT Southwestern Medical Center (UTSW) together will launch a new transformation school slated to open its doors next fall.

High levels of physical activity may mitigate brain loss in adults and help maintain long-term cognitive health, researchers at UT Southwestern Medical Center report in a study published in the Journal of Applied Physiology.

A well-known class of drugs used to manage Type 2 diabetes and control weight could offer hope for patients who also struggle with related chronic kidney disease (CKD), researchers at UT Southwestern Medical Center found.

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical Center researchers have identified a protein that plays a key role in cell adhesion and movement.

Using a powerful microscopy technique, a team led by researchers at UT Southwestern Medical Center has gained insights into how the body uses vitamin K, an essential nutrient that plays a pivotal role in blood clotting and other physiological functions.

A multidisciplinary team of UT Southwestern Medical Center specialists, led by Nader Pouratian, M.D., Ph.D., and Peter Tsai, M.D., Ph.D., has received a grant worth up to $5 million from the Raynor Cerebellum Project to develop neuromodulation therapies for patients with cerebellar disorders of the brain.

An emotional overattachment to social media may be associated with increased severity of mental health symptoms among young people being treated for depression, anxiety, and suicidal thoughts, according to researchers at UT Southwestern Medical Center.