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Mitochondria that power cellular activity fragment and change shape in breast cancer cells that migrate to the brain, an adaptation that appears necessary for the cells to survive, UT Southwestern Medical Center researchers report in a new study. The findings, published in Nature Cancer, could lead to new ways to prevent brain metastases, or the spread of cells from primary tumors to the brain.

Whether it’s after a natural disaster, a fatal shooting, or a tragedy closer to home, parents may find themselves trying to navigate difficult conversations with their children. What to say is just as important as what not to say, according to experts at UT Southwestern Medical Center. Children are naturally curious and may have questions, or they may be worried about their own safety.

Seemingly healthy people whose blood contained antibodies associated with a condition called antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event such as a heart attack or stroke than those without, a study led by UT Southwestern scientists shows.

The painful experience of having a kidney stone has become more common in recent years, including in Texas, part of the “Stone Belt” where hot weather can cause dehydration. But small dietary changes as well as drinking lots of water can help avert the discomfort, says a board-certified physician assistant in the Department of Urology at UT Southwestern Medical Center.

Two postdoctoral researchers at UT Southwestern Medical Center are among 25 early-career scientists nationwide selected as Howard Hughes Medical Institute (HHMI) Hanna H. Gray Fellows for 2023.

UT Southwestern investigators are working diligently across the spectrum of biomedical research and clinical care to unravel the complexities of human biology. Their research is central to our mission. Read more in this edition of Discovery at UT Southwestern.

Researchers at UT Southwestern Medical Center have discovered how healthy bacteria can escape the intestine, travel to lymph nodes and cancerous tumors elsewhere in the body, and boost the effectiveness of certain immunotherapy drugs.

How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.

Cell membrane protrusions called blebs that typically signify the end of life for healthy cells do the opposite for melanoma cells, activating processes in these cells that help them to survive and spread, a UT Southwestern study suggests.

– The brain circuitry that is disrupted in Alzheimer’s disease appears to influence memory through a type of brain wave known as theta oscillation, a team led by UT Southwestern Medical Center researchers report.