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A preclinical model developed at UT Southwestern Medical Center that recapitulates a rare infant-onset form of diabetes suggests the condition stems from gradual damage to the pancreas through misregulation of a molecular pathway called the unfolded protein response (UPR).

A majority of Americans suffering from heart failure face substantial socioeconomic challenges, researchers at UT Southwestern Medical Center found.A majority of Americans suffering from heart failure face substantial socioeconomic challenges, researchers at UT Southwestern Medical Center found. The study revealed that 8 in 10 ambulatory heart failure patients are adversely affected by two or more social determinants of health (SDOH).

Zhijian “James” Chen, Ph.D., Professor of Molecular Biology at UT Southwestern Medical Center, has been awarded the 2023 Louisa Gross Horwitz Prize in recognition of his groundbreaking work on innate immunity.

Nearly half of Texas youths being treated for depression or suicidal thoughts reported at least one suicide attempt, and 90% had experienced suicidal ideation, according to a study led by UT Southwestern Medical Center researchers.

Two postdoctoral researchers at UT Southwestern Medical Center are among 25 early-career scientists nationwide selected as Howard Hughes Medical Institute (HHMI) Hanna H. Gray Fellows for 2023.

A novel combination of drugs successfully killed breast cells carrying double mutations in the HER2 gene that had rendered them resistant to a commonly used cancer therapy, a study led by UT Southwestern Medical Center researchers showed.

The Peter O’Donnell Jr. School of Public Health will strive to address the world’s most pressing public health problems through creative cross-disciplinary research and a focus on effecting change, said Saad B. Omer, M.B.B.S., M.P.H., Ph.D., who joined UT Southwestern Medical Center on June 1 as the school’s Founding Dean.

Researchers led by a team at UT Southwestern Medical Center have identified cellular and molecular features of the brain that set modern humans apart from their closest primate relatives and ancient human ancestors. The findings, published in Nature, offer new insights into human brain evolution.

An innovative virtual reality (VR) training tool could soon play a major role in helping physicians recognize and respond to potentially violent patient encounters.

A mammalian protein previously shown by UT Southwestern microbiologists to inhibit the virus that causes COVID-19 in cell culture also protected live mouse models, significantly limiting infection in the lung cells and diminishing the symptoms.