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Combining a common chemotherapy drug with an experimental nanotechnology allowed the drug to cross the blood-brain barrier and increased the survival rate in a mouse model of glioblastoma up to 50%, a team led by researchers from UT Southwestern Medical Center and UT Dallas found.

Pelvic floor disorders (PFDs), which occur when women’s pelvic floor muscles are weakened or injured, significantly affect quality of life and require surgery for hundreds of thousands in the U.S. each year. Now a study led by UT Southwestern Medical Center researchers has found a noninvasive test that could identify women at risk for these conditions and improve treatment.

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.

Hepatocellular carcinoma (HCC), the most common type of liver cancer, can place a significant financial burden on patients, according to an analysis led by a researcher at UT Southwestern Medical Center.

Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence (AI) model to improve the detection of breast cancer metastasis, which could reduce the need for needle or surgical biopsies.

An increased concentration of the hormone leptin in fat cells is believed to be responsible for weight gain associated with antipsychotic drugs.

– Sex-specific differences in the knee joint should be considered as early as childhood to help prevent higher incidence and severity of knee osteoarthritis (OA) in women later in life, UT Southwestern Medical Center researchers propose in a review of clinical data.

As the warm weather and summer vacations draw more people outdoors, a UT Southwestern Medical Center cancer specialist is reminding everyone to stay vigilant of potential sun damage.

A study of mutant models of fragile X syndrome (FXS), a genetic disorder related to autism and intellectual disability, shows that activation of the cerebellum mitigates aberrant responses in sensory processing areas of the brain and improves neurodevelopmental behaviors.

UT Southwestern Medical Center is the No. 1 hospital in Dallas-Fort Worth for the eighth consecutive year and ranks among the nation’s top hospitals for care in 11 specialties – the most of any hospital in Texas, according to U.S. News & World Report’s annual Best Hospitals list released today.