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A team led by UT Southwestern Medical Center researchers has uncovered a molecular pathway that links obesity to widespread inflammation, providing long-sought insight into why obesity increases the risk of Type 2 diabetes, cardiovascular disease, fatty liver disease, and certain cancers.

Two UT Southwestern Medical Center researchers have identified a protein that plays a key role in controlling the liver’s release of cholesterol-carrying lipoproteins into the bloodstream, a discovery that could lead to new treatments for atherosclerotic heart disease and fatty liver disease.

A designer version of the tau protein, developed by a team led by UT Southwestern Medical Center researchers, maintains its biological function while resisting aggregation, a pathological trait linked to neurodegenerative diseases called tauopathies.

A multidisciplinary team of UT Southwestern Medical Center specialists, led by Nader Pouratian, M.D., Ph.D., and Peter Tsai, M.D., Ph.D., has received a grant worth up to $5 million from the Raynor Cerebellum Project to develop neuromodulation therapies for patients with cerebellar disorders of the brain.

High levels of physical activity may mitigate brain loss in adults and help maintain long-term cognitive health, researchers at UT Southwestern Medical Center report in a study published in the Journal of Applied Physiology.

A team of researchers including UT Southwestern Medical Center Pediatrics faculty members Jo-Ann Nesiama, M.D., Professor, and Geetanjali Srivastava, M.D., M.P.H., Associate Professor, collected data on 5,641 ED visits for pediatric anaphylaxis between 2016 and 2019 from 30 hospitals in the U.S. and one in Canada.

An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer (NK) cells in an animal model, a study led by UT Southwestern Medical Center researchers shows.

A well-known class of drugs used to manage Type 2 diabetes and control weight could offer hope for patients who also struggle with related chronic kidney disease (CKD), researchers at UT Southwestern Medical Center found.

Researchers at UT Southwestern Medical Center have linked blindness in animal models to a brain-wide cellular stress response that’s a common risk factor for dementia. Their findings, published in Nature Communications, could help explain the connection between vision or hearing loss and dementia.

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical Center researchers have identified a protein that plays a key role in cell adhesion and movement.