Whole Brain Microscopy Publications
2025
Zeiss Axioscan.Z1
- Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors
- Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis
- SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice
- Spontaneous pathology in PS19 tauopathy mice progresses via brain networks
- Nitrous oxide enhances MR-guided focused ultrasound delivery of gene therapy to the murine hippocampus
Zeiss Axioscan.A1
Zeiss Axioscan 7
- Development and characterization of an Sf-1-Flp mouse model
- The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
- Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction
- Leptin as a key driver for organ fibrogenesis
Hamamatsu Nanozoomer S60
- Female sex hormones exacerbate retinal neurodegeneration
- Pharmacological reduction of reverse-translated hippocampal hyperactivity in mouse: relevance for psychosis
- Lithium exacerbates Lafora body formation in the Epm2a-/- Lafora disease mouse model
- High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
- Dual SORT LNPs for multi-organ base editing
- Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
Leica CM1950 Cryostat
TissueCyte 1000
- SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice
- Spontaneous pathology in PS19 tauopathy mice progresses via brain networks
- 2024
- Severely polarized extracellular acidity around tumour cells
- CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses
- Metal substitutions incarbonic anhydrase: a halide ion probe study
- A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer
- De novo and salvage purine synthesis pathways across tissues and tumors
- In vivo editing of lung stem cells for durable gene correction in mice
- Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis
- Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
- Acute vasculature disruption in orthotopic kidney tumors based on vascular disrupting agent (OXi8007) examined by multispectral optoacoustic tomography (MSOT)
- Development of betabodies: The next generation of phosphatidylserine targeting agents
- Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs
- An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis
- Expression and distribution of rAAV9 intrathecally administered in juvenile to adolescent mice
- AXL-TBK1 driven AKT3 activation promotes metastasis
- Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
- PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
- Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells
- Metabolic inflexibility promotes mitochondrial health during liver regeneration
- Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis
- Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism
- Vegfc-expressing cells form heterotopic bone after musculoskeletal injury
- Female sex hormones exacerbate retinal neurodegeneration
- Somatic and autonomic nerve density and distribution within the clitoris: an immunohistochemical study in adult female cadavers
- Clinicopathologic Dissociation: Robust Lafora Body Accumulation in Malin KO Mice Without Observable Changes in Home-Cage Behavior
- 2023
- Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption
- Pleiotrophin drives a prometastatic immune niche in breast cancer
- Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
- Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer's phenotypes without blocking peripheral T cell IL-2 response
- Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System
- Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images
- In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration
- Tau seeding without tauopathy
- Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models
- Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden
- CSTB gene replacement improves neuroinflammation, neurodegeneration and ataxia in murine type 1 progressive myoclonus epilepsy
- Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
- Neuronal binding by antibodies can be influenced by low pH stress during the isolation procedure
- Brain-wide circuit-specific targeting of astrocytes
- Lactate metabolism is essential in early-onset mitochondrial myopathy
- Gpr149 is involved in energy homeostasis in the male mouse
- Anatomic relationships of the clitoral body, bulbs of the vestibule, and urethra
- Somatic and autonomic nerve density of the urethra, periurethral tissue, and anterior vaginal wall: an immunohistochemical study in adult female cadavers
- Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer
- 2022
- AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer
- AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
- Seed-competent tau monomer initiates pathology in a tauopathy mouse model
- Aged Mouse Hippocampus Exhibits Signs of Chronic Hypoxia and an Impaired HIF-Controlled Response to Acute Hypoxic Exposures
- Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
- Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea
- AAV-Mediated Artificial miRNA Reduces Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models
- Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke
- Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
- A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior
- The immunopathology of B lymphocytes during stroke-induced injury and repair
- A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior
- Establishment of patient-derived organoid models of lower-grade glioma
- Small Extracellular Vesicles in Milk Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J Mice
- LZK-dependent stimulation of astrocyte reactivity promotes corticospinal axon sprouting
- Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification
- 5-Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
- Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
- Lenvatinib inhibits the growth of gastric cancer patient-derived xenografts generated from a heterogeneous population
- In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
- Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer
- PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
- Repeated trans-arterial treatments of LDL-DHA nanoparticles induce multiple pathways of tumor cell death in hepatocellular carcinoma bearing rats
- An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
- 2021
- Modulation of tactile feedback for the execution of dexterous movement
- VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment
- AXL Is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer
- NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
- Targeting Gys1 with AAV-SaCas9 Decreases Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models
- Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model
- Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice
- Single-cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions
- Anterograde transneuronal tracing and genetic control with engineered yellow fever vaccine YFV-17D
- Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C
- Liver homeostasis is maintained by midlobular zone 2 hepatocytes
- 2020
- A synthetic heparinoid blocks Tau aggregate cell uptake and amplification
- Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window
- Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species
- Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development
- Sorting nexin 5 mediates virus-induced autophagy and immunity
- Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia
- Physiology-forward identification of bile acid-sensitive vomeronasal receptors
- SLC43A3 Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine
- B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice
- Impaired meningeal lymphatic vessel development worsens stroke outcome
- Urethral luminal epithelia are castration-insensitive cells of the proximal prostate
- Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP
- Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma
- Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons
- Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes
- Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury
- 2019
- Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer
- Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas
- Gross and Histologic Anatomy of the Pelvic Ureter: Clinical Applications to Pelvic Surgery
- Anatomy, histology, and nerve density of clitoris and associated structures: clinical applications to vulvar surgery
- Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release
- Oxygen-sensitive MRI assessment of tumor response to hypoxic gas breathing challenge
- Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency
- Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth
- Serial Multiphoton Tomography and Analysis of Volumetric Images of the Mouse Brain
- Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention
- Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector
- Impaired meningeal lymphatic vessel development worsens stroke outcome
- Visualization and Quantification of Post-stroke Neural Connectivity and Neuroinflammation Using Serial Two-Photon Tomography in the Whole Mouse Brain
- STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
- 2018
- A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis
- Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues
- Sitravatinib potentiates immune checkpoint blockade in refractory cancer models
- Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer
- Gross and histologic relationships of the retropubic urethra to lateral pelvic sidewall and anterior vaginal wall in female cadavers: clinical applications to retropubic surgery
- Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS
- Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury
- Pin1 mediates Aβ42-induced dendritic spine loss
- Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli
- Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
- Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice
- Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology
- Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance
- Proton radiation-induced cancer progression
- Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
- ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism
- 2017
- Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
- Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue
- Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
- Repression by PRDM13 is critical for generating precision in neuronal identity
- The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells
- Experience-Dependent Plasticity in Accessory Olfactory Bulb Interneurons following Male-Male Social Interaction
- Persistence of parenchymal and perivascular T-cells in treatment-refractory anti-N-methyl-D-aspartate receptor encephalitis
- microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
- Kctd13 deletion reduces synaptic transmission via increased RhoA
- Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer
- Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer
- Laquinimod has no effects on brain volume or cellular CNS composition in the F1 3xTg-AD/C3H mouse model of Alzheimer's disease
- Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis
- Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice
- 2016
- Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production
- Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats
- Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound
- Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
- An automated task for the training and assessment of distal forelimb function in a mouse model of ischemic stroke
- Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
- Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization
- From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers
- Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients
- Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage
- Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice
- 2016
- The role of ventral striatal cAMP signaling in stress-induced behaviors
- The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung
- Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function
- A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients